MeSH Browser

MeSH Heading: Kleine-Levin Syndrome
Tree Number(s): C10.886.425.800.200.500; F03.870.400.800.200.500
Unique ID: D017593
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D017593
Scope Note: A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)
Entry Term(s): Familial Hibernation (Kleine-Levin) Syndrome; Familial Kleine-Levin Syndrome; Hypersomnia, Periodic; Kleine-Levin Hibernation Syndrome; Kleine-Levin-Critchley Syndrome
Previous Indexing: Eating Disorders (1966-1976); Hunger (1966-1971); Hyperphagia (1981-1993); Hypersomnia (1975-1993); Sleep Disorders (1966-1979)
Public MeSH Note: 94
History Note: 94
Date Established: 1994/01/01
Date of Entry: 1992/12/28
Revision Date: 2012/07/03

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Concept UI: M0026659
Scope Note: A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)
Terms: Kleine-Levin Syndrome Preferred Term
Term UI T052755
Date01/01/1999
LexicalTag EPO
ThesaurusID; Hypersomnia, Periodic
Term UI T052756
Date06/18/1992
LexicalTag NON
ThesaurusID NLM (1994); Kleine-Levin Hibernation Syndrome
Term UI T769530
Date04/15/2010
LexicalTag EPO
ThesaurusID; Kleine-Levin-Critchley Syndrome
Term UI T052754
Date06/18/1992
LexicalTag EPO
ThesaurusID NLM (1994)

Kleine-Levin Syndrome MeSH Descriptor Data 2025