MeSH Browser

MeSH Heading: Neurofibrosarcoma
Tree Number(s): C04.557.450.565.590.350.590; C04.557.450.795.350.590; C04.557.580.600.580.795; C10.551.775.500.750.750; C10.668.829.725.500.600.600
Unique ID: D018319
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018319
Annotation: coordinate IM with precoordinated organ/neoplasm term (IM)
Scope Note: A malignant tumor that arises from small cutaneous nerves, is locally aggressive, and has a potential for metastasis. Characteristic histopathologic features include proliferating atypical spindle cells with slender wavy and pointed nuclei, hypocellular areas, and areas featuring organized whorls of fibroblastic proliferation. The most common primary sites are the extremities, retroperitoneum, and trunk. These tumors tend to present in childhood, often in association with NEUROFIBROMATOSIS 1. (From DeVita et al., Cancer: Principles & Practice of Oncology, 5th ed, p1662; Mayo Clin Proc 1990 Feb;65(2):164-72)
Entry Term(s): MPNST; Malignant Neurilemmoma; Malignant Neurilemoma; Malignant Peripheral Nerve Sheath Tumor; Malignant Peripheral Nerve Sheath Tumors; Neurilemmosarcoma; Peripheral Nerve Sheath Tumors, Malignant; Sarcoma, Neurogenic; Schwannoma, Malignant
Previous Indexing: Fibrosarcoma (1966-1978); Neurofibroma (1969-1993)
Public MeSH Note: 1994; for Malignant Peripheral Nerve Sheath Tumors, see Neurilemoma 2000-2018
History Note: 1994; for Malignant Peripheral Nerve Sheath Tumors, use Neurilemoma 2000-2018
Date Established: 1994/01/01
Date of Entry: 1993/06/25
Revision Date: 2018/03/08

Allowable Qualifiers: blood (BL)

blood supply (BS)

cerebrospinal fluid (CF)

chemically induced (CI)

chemistry (CH)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

secondary (SC)

surgery (SU)

therapy (TH)

ultrastructure (UL)

urine (UR)

veterinary (VE)

virology (VI)

Neoplasms [C04]
- Neoplasms by Histologic Type [C04.557]
  - Neoplasms, Connective and Soft Tissue [C04.557.450]
    - Neoplasms, Connective Tissue [C04.557.450.565]
      - Neoplasms, Fibrous Tissue [C04.557.450.565.590]
        
        Fibrosarcoma [C04.557.450.565.590.350]
        
        Dermatofibrosarcoma [C04.557.450.565.590.350.320]
        
        Neurofibrosarcoma [C04.557.450.565.590.350.590]

Neoplasms [C04]
- Neoplasms by Histologic Type [C04.557]
  - Neoplasms, Connective and Soft Tissue [C04.557.450]
    - Sarcoma [C04.557.450.795]
      - Fibrosarcoma [C04.557.450.795.350]
        
        Dermatofibrosarcoma [C04.557.450.795.350.320]
        
        Neurofibrosarcoma [C04.557.450.795.350.590]

Neoplasms [C04]
- Neoplasms by Histologic Type [C04.557]
  - Neoplasms, Nerve Tissue [C04.557.580]
    - Nerve Sheath Neoplasms [C04.557.580.600]
      - Neurofibroma [C04.557.580.600.580]
        
        Neurofibroma, Plexiform [C04.557.580.600.580.585]
        
        Neurofibromatoses [C04.557.580.600.580.590]
        
        Neurofibrosarcoma [C04.557.580.600.580.795]

Nervous System Diseases [C10]
- Nervous System Neoplasms [C10.551]
  - Peripheral Nervous System Neoplasms [C10.551.775]
    - Nerve Sheath Neoplasms [C10.551.775.500]
      - Neurofibroma [C10.551.775.500.750]
        
        Neurofibroma, Plexiform [C10.551.775.500.750.500]
        
        Neurofibrosarcoma [C10.551.775.500.750.750]

Nervous System Diseases [C10]
- Neuromuscular Diseases [C10.668]
  - Peripheral Nervous System Diseases [C10.668.829]
    - Peripheral Nervous System Neoplasms [C10.668.829.725]
      - Nerve Sheath Neoplasms [C10.668.829.725.500]
        
        Neurofibroma [C10.668.829.725.500.600]
        
        Neurofibroma, Plexiform [C10.668.829.725.500.600.500]
        
        Neurofibrosarcoma [C10.668.829.725.500.600.600]

Neurofibrosarcoma Preferred

Malignant Peripheral Nerve Sheath Tumors Narrower

Concept UI: M0336462
Scope Note: A malignant neurilemmoma with nerve sheath differentiation. It is often associated with NEUROFIBROMATOSIS 1 and RHABDOMYOSARCOMA.
Terms: Malignant Peripheral Nerve Sheath Tumors Preferred Term
Term UI T371150
Date11/08/1999
LexicalTag NON
ThesaurusID NLM (2000); Neurilemmosarcoma
Term UI T028143
Date07/10/1996
LexicalTag NON
ThesaurusID NLM (1998); MPNST
Term UI T371147
Date11/08/1999
LexicalTag ABB
ThesaurusID NLM (2000); Peripheral Nerve Sheath Tumors, Malignant
Term UI T371151
Date11/08/1999
LexicalTag NON
ThesaurusID NLM (2000); Malignant Neurilemoma
Term UI T371156
Date11/04/1999
LexicalTag NON
ThesaurusID NLM (2000); Schwannoma, Malignant
Term UI T781858
Date12/09/2010
LexicalTag NON
ThesaurusID; Malignant Peripheral Nerve Sheath Tumor
Term UI T000937762
Date12/14/2017
LexicalTag NON
ThesaurusID NLM (2019); Malignant Neurilemmoma
Term UI T839571
Date04/02/2013
LexicalTag NON
ThesaurusID NLM (2014)

Neurofibrosarcoma MeSH Descriptor Data 2025