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Spheroids, Cellular MeSH Descriptor Data 2023

MeSH Heading
Spheroids, Cellular
Tree Number(s)
Unique ID
RDF Unique Identifier
do not confuse with "spheroid bodies" referring to axons in neuropathol; if tumor spheroids coordinate with TUMOR CELLS, CULTURED
Scope Note
Spherical, heterogeneous aggregates of proliferating, quiescent, and necrotic cells in culture that retain three-dimensional architecture and tissue-specific functions. The ability to form spheroids is a characteristic trait of CULTURED TUMOR CELLS derived from solid TUMORS. Cells from normal tissues can also form spheroids. They represent an in-vitro model for studies of the biology of both normal and malignant cells. (From Bjerkvig, Spheroid Culture in Cancer Research, 1992, p4)
Entry Term(s)
Multicellular Spheroids
Previous Indexing
Cells, Cultured (1972-1995)
Tissue Culture (1966-1971)
Tumor Cells, Cultured (1988-1995)
Public MeSH Note
2004(1996); see SPHEROIDS 1996-2003
History Note
Date Established
Date of Entry
Revision Date
Spheroids, Cellular Preferred
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