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Genistein
MeSH Descriptor Data 2025
Details
Qualifiers
MeSH Tree Structures
Concepts
MeSH Heading
Genistein
Tree Number(s)
D03.383.663.283.266.450.400.375
D03.633.100.150.266.450.400.375
Unique ID
D019833
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019833
Scope Note
An isoflavonoid derived from soy products. It inhibits
PROTEIN-TYROSINE KINASE
and topoisomerase-II (
DNA TOPOISOMERASES, TYPE II
); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce
G2 PHASE
arrest in human and murine cell lines and inhibits
PROTEIN-TYROSINE KINASE
.
Entry Term(s)
Genestein
Pharm Action
Anticarcinogenic Agents
Protein Kinase Inhibitors
Phytoestrogens
Related Numbers
446-72-0
Previous Indexing
Isoflavones (1976-1997)
Public MeSH Note
98; GENISTEIN was indexed under ISOFLAVONES 1976-97
History Note
98; use GENISTEIN (NM) 1980-97
Date Established
1998/01/01
Date of Entry
1997/06/20
Revision Date
2016/05/31
Allowable Qualifiers
administration & dosage (AD)
adverse effects (AE)
agonists (AG)
analogs & derivatives (AA)
analysis (AN)
antagonists & inhibitors (AI)
blood (BL)
cerebrospinal fluid (CF)
chemical synthesis (CS)
chemistry (CH)
classification (CL)
economics (EC)
history (HI)
immunology (IM)
isolation & purification (IP)
metabolism (ME)
pharmacokinetics (PK)
pharmacology (PD)
poisoning (PO)
radiation effects (RE)
standards (ST)
supply & distribution (SD)
therapeutic use (TU)
toxicity (TO)
urine (UR)
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Pyrans [D03.383.663]
Benzopyrans [D03.383.663.283]
Chromones [D03.383.663.283.266]
Flavonoids [D03.383.663.283.266.450]
Isoflavones [D03.383.663.283.266.450.400]
Coumestrol [D03.383.663.283.266.450.400.187]
Genistein [D03.383.663.283.266.450.400.375]
Pterocarpans [D03.383.663.283.266.450.400.687]
Rotenone [D03.383.663.283.266.450.400.843]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 2-Ring [D03.633.100]
Benzopyrans [D03.633.100.150]
Chromones [D03.633.100.150.266]
Flavonoids [D03.633.100.150.266.450]
Isoflavones [D03.633.100.150.266.450.400]
Coumestrol [D03.633.100.150.266.450.400.187]
Equol [D03.633.100.150.266.450.400.281]
Genistein [D03.633.100.150.266.450.400.375]
Pterocarpans [D03.633.100.150.266.450.400.687]
Rotenone [D03.633.100.150.266.450.400.843]
Expand All
Collapse All
Genistein
Preferred
Concept UI
M0029441
Related Numbers
446-72-0
Scope Note
An isoflavonoid derived from soy products. It inhibits
PROTEIN-TYROSINE KINASE
and topoisomerase-II (
DNA TOPOISOMERASES, TYPE II
); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce
G2 PHASE
arrest in human and murine cell lines and inhibits
PROTEIN-TYROSINE KINASE
.
Terms
Genistein
Preferred Term
Term UI
T059010
Date
01/01/1999
LexicalTag
NON
ThesaurusID
Genestein
Term UI
T059011
Date
01/13/1997
LexicalTag
NON
ThesaurusID
NLM (1998)
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