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N-Acetylgalactosamine-4-Sulfatase MeSH Descriptor Data 2022


MeSH Heading
N-Acetylgalactosamine-4-Sulfatase
Tree Number(s)
D08.811.277.352.827.070.060
D08.811.277.352.827.180.175.060
Unique ID
D020051
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020051
Scope Note
An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.
Entry Term(s)
Arylsulfatase B
Arylsulfatase B1
Arylsulfatase B2
N-Acetylgalactosamine 4-Sulfatase
N-Acetylgalactosamine-4-sulfate Sulfatase
N-Acetylgalactosamine-4-sulphate Sulphatase
Registry Number
EC 3.1.6.12
CAS Type 1 Name
N-Acetyl-D-Galactosamine-4-sulfate 4-sulfohydrolase
Previous Indexing
Sulfatases (1988-1998)
Public MeSH Note
99; for ARYLSULFATASE B see CHONDRO-4-SULFATASE 1975-98; N-ACETYLGALACTOSAMINE-4-SULFATE SULFATASE (now N-ACETYLGALACTOSAMINE-4-SULFATASE) was indexed under SULFATASES 1988-98
History Note
99; for ARYLSULFATASE B use CHONDRO-4-SULFATASE 1975-98; use N-ACETYLGALACTOSAMINE-4-SULFATASE (NM) 1988-98
Entry Combination
deficiency:Mucopolysaccharidosis VI
Date Established
1999/01/01
Date of Entry
1998/06/10
Revision Date
2016/06/28
N-Acetylgalactosamine-4-Sulfatase Preferred
Arylsulfatase B2 Narrower
Arylsulfatase B1 Narrower
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