MeSH Browser

MeSH Heading: N-Acetylgalactosamine-4-Sulfatase
Tree Number(s): D08.811.277.352.827.070.060; D08.811.277.352.827.180.175.060
Unique ID: D020051
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020051
Scope Note: An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.
Entry Term(s): Arylsulfatase B; Arylsulfatase B1; Arylsulfatase B2; N-Acetylgalactosamine 4-Sulfatase; N-Acetylgalactosamine-4-sulfate Sulfatase; N-Acetylgalactosamine-4-sulphate Sulphatase
Registry Number: EC 3.1.6.12
CAS Type 1 Name: N-Acetyl-D-Galactosamine-4-sulfate 4-sulfohydrolase
Previous Indexing: Sulfatases (1988-1998)
Public MeSH Note: 99; for ARYLSULFATASE B see CHONDRO-4-SULFATASE 1975-98; N-ACETYLGALACTOSAMINE-4-SULFATE SULFATASE (now N-ACETYLGALACTOSAMINE-4-SULFATASE) was indexed under SULFATASES 1988-98
History Note: 99; for ARYLSULFATASE B use CHONDRO-4-SULFATASE 1975-98; use N-ACETYLGALACTOSAMINE-4-SULFATASE (NM) 1988-98
Entry Combination: deficiency:Mucopolysaccharidosis VI
Date Established: 1999/01/01
Date of Entry: 1998/06/10
Revision Date: 2016/06/28

Entry Combination: deficiency:Mucopolysaccharidosis VI
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0029765
Registry Number: EC 3.1.6.12
Scope Note: An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.
Terms: N-Acetylgalactosamine-4-Sulfatase Preferred Term
Term UI T059722
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1999); N-Acetylgalactosamine 4-Sulfatase
Term UI T059721
Date10/28/1997
LexicalTag NON
ThesaurusID NLM (1999); N-Acetylgalactosamine-4-sulphate Sulphatase
Term UI T059724
Date10/28/1997
LexicalTag NON
ThesaurusID NLM (1999); N-Acetylgalactosamine-4-sulfate Sulfatase
Term UI T059723
Date10/28/1997
LexicalTag NON
ThesaurusID NLM (1999); Arylsulfatase B
Term UI T059720
Date10/28/1997
LexicalTag NON
ThesaurusID NLM (1999)

N-Acetylgalactosamine-4-Sulfatase MeSH Descriptor Data 2023