MeSH Browser

MeSH Heading: Selective Estrogen Receptor Modulators
Tree Number(s): D06.347.360.827; D27.505.696.399.450.360.827
Unique ID: D020845
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020845
Annotation: do not confuse with ESTROGEN RECEPTOR MODULATORS
Scope Note: A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)
Entry Version: SELECTIVE ESTROGEN RECEPT MODULATORS
Entry Term(s): Estrogen Receptor Modulator, Selective; Estrogen Receptor Modulators, Selective; SERM; SERMs; Selective Estrogen Receptor Modulator
Previous Indexing: Receptors, Estrogen (1996-1999)
See Also: Bone Density Conservation Agents
Public MeSH Note: 2000
History Note: 2000
Date Established: 2000/01/01
Date of Entry: 1999/11/08
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0328354
Scope Note: A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)
Terms: Selective Estrogen Receptor Modulators Preferred Term
Term UI T358354
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); SERM
Term UI T365817
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); SERMs
Term UI T365814
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Estrogen Receptor Modulator, Selective
Term UI T365815
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Estrogen Receptor Modulators, Selective
Term UI T365818
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Selective Estrogen Receptor Modulator
Term UI T365816
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000)

Selective Estrogen Receptor Modulators MeSH Descriptor Data 2025