MeSH Browser

MeSH Heading: Fusion Regulatory Protein-1
Tree Number(s): D12.776.157.530.200.374.750.500; D12.776.157.530.200.500.500.500; D12.776.157.530.937.313.500; D12.776.543.585.200.374.750.500; D12.776.543.585.200.500.500.500; D12.776.543.585.937.313.500
Unique ID: D027261
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D027261
Scope Note: A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (FUSION REGULATORY PROTEIN 1, HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (FUSION REGULATORY PROTEIN 1, LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
Entry Term(s): 4F2 Antigen; 4F2-antigen; Antigen 4F2; Antigens, CD98; CD98 Antigen; CD98 Antigens; CD98 Transport Proteins; FRP-1 protein; H4F2 Antigen; Human 4F2 Antigen; Human 4F2 Cell-Surface Antigen; Human Lymphocyte Activation Antigen 4F2
Previous Indexing: Antigens, CD (1996-2001); Antigens, Surface (1989-1995); Carrier Proteins (1996-2001)
Public MeSH Note: 2018; see ANTIGENS, CD98 1988-2017; FUSION REGULATORY PROTEIN-1 was indexed under CARRIER PROTEINS 1996-2001; under ANTIGENS CD 1996-2001; and under ANTIGENS, SURFACE 1989-1995
History Note: 2018 (1988)
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Amino Acid Transport Systems [D12.776.157.530.200]
        
        Amino Acid Transport Systems, Basic [D12.776.157.530.200.374]
        
        Amino Acid Transport System y+L [D12.776.157.530.200.374.750]
        
        Fusion Regulatory Protein-1 [D12.776.157.530.200.374.750.500]
        
        Fusion Regulatory Protein 1, Heavy Chain [D12.776.157.530.200.374.750.500.250]
        
        Fusion Regulatory Protein 1, Light Chains [D12.776.157.530.200.374.750.500.625]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Amino Acid Transport Systems [D12.776.157.530.200]
        
        Amino Acid Transport Systems, Neutral [D12.776.157.530.200.500]
        
        Amino Acid Transport System L [D12.776.157.530.200.500.500]
        
        Fusion Regulatory Protein-1 [D12.776.157.530.200.500.500.500]
        
        Fusion Regulatory Protein 1, Heavy Chain [D12.776.157.530.200.500.500.500.250]
        
        Fusion Regulatory Protein 1, Light Chains [D12.776.157.530.200.500.500.500.300]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Solute Carrier Proteins [D12.776.157.530.937]
        
        Amino Acid Transport System y+L [D12.776.157.530.937.313]
        
        Fusion Regulatory Protein-1 [D12.776.157.530.937.313.500]
        
        Fusion Regulatory Protein 1, Heavy Chain [D12.776.157.530.937.313.500.250]
        
        Fusion Regulatory Protein 1, Light Chains [D12.776.157.530.937.313.500.625]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Amino Acid Transport Systems [D12.776.543.585.200]
        
        Amino Acid Transport Systems, Basic [D12.776.543.585.200.374]
        
        Amino Acid Transport System y+L [D12.776.543.585.200.374.750]
        
        Fusion Regulatory Protein-1 [D12.776.543.585.200.374.750.500]
        
        Fusion Regulatory Protein 1, Heavy Chain [D12.776.543.585.200.374.750.500.250]
        
        Fusion Regulatory Protein 1, Light Chains [D12.776.543.585.200.374.750.500.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Amino Acid Transport Systems [D12.776.543.585.200]
        
        Amino Acid Transport Systems, Neutral [D12.776.543.585.200.500]
        
        Amino Acid Transport System L [D12.776.543.585.200.500.500]
        
        Fusion Regulatory Protein-1 [D12.776.543.585.200.500.500.500]
        
        Fusion Regulatory Protein 1, Heavy Chain [D12.776.543.585.200.500.500.500.250]
        
        Fusion Regulatory Protein 1, Light Chains [D12.776.543.585.200.500.500.500.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Solute Carrier Proteins [D12.776.543.585.937]
        
        Amino Acid Transport System y+L [D12.776.543.585.937.313]
        
        Fusion Regulatory Protein-1 [D12.776.543.585.937.313.500]
        
        Fusion Regulatory Protein 1, Heavy Chain [D12.776.543.585.937.313.500.250]
        
        Fusion Regulatory Protein 1, Light Chains [D12.776.543.585.937.313.500.625]

Fusion Regulatory Protein-1 Preferred

Concept UI: M0159086
Scope Note: A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (FUSION REGULATORY PROTEIN 1, HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (FUSION REGULATORY PROTEIN 1, LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
Terms: Fusion Regulatory Protein-1 Preferred Term
Term UI T189086
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); 4F2-antigen
Term UI T189080
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); CD98 Antigens
Term UI T189082
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); FRP-1 protein
Term UI T189083
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); Antigen 4F2
Term UI T189091
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); Antigens, CD98
Term UI T437650
Date03/02/2001
LexicalTag ABX
ThesaurusID NLM (2002); CD98 Antigen
Term UI T443150
Date04/17/2001
LexicalTag ABX
ThesaurusID NLM (2002); 4F2 Antigen
Term UI T189078
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); CD98 Transport Proteins
Term UI T446074
Date05/09/2001
LexicalTag ABX
ThesaurusID NLM (2002)

Human 4F2 Antigen Narrower

Concept UI: M0360036
Terms: Human 4F2 Antigen Preferred Term
Term UI T411170
Date04/05/2000
LexicalTag ACX
ThesaurusID NLM (2002); Human 4F2 Cell-Surface Antigen
Term UI T411171
Date04/05/2000
LexicalTag ACX
ThesaurusID NLM (2002); Human Lymphocyte Activation Antigen 4F2
Term UI T411172
Date04/05/2000
LexicalTag ACX
ThesaurusID NLM (2002); H4F2 Antigen
Term UI T437727
Date03/02/2001
LexicalTag ACX
ThesaurusID NLM (2002)

Fusion Regulatory Protein-1 MeSH Descriptor Data 2025