MeSH Browser

MeSH Heading: Neural Cell Adhesion Molecule L1
Tree Number(s): D09.400.430.890.200.250.520.578; D12.776.395.550.200.250.520.578; D12.776.543.550.200.250.520.578; D23.050.301.350.250.520.578
Unique ID: D039842
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039842
Scope Note: A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
Entry Term(s): CALL Protein; CamL1 Gene Product; Cell Adhesion Molecule L1; Cell Surface Glycoprotein L1; F11 Glycoprotein; L1 Cell Adhesion Molecule; L1CAM; NGF-Inducible Glycoprotein; NILE Glycoprotein; NILE Protein; Nerve Growth Factor-Inducible Large External Glycoprotein; Neural Adhesion Molecule L1
Previous Indexing: Antigens, Surface (1992-2002); Cell Adhesion Molecules, Neuronal (1992-2002); Membrane Glycoproteins (1992-2002); Neural Cell Adhesion Molecules (1996-2002)
Public MeSH Note: 2003; NERVE GROWTH FACTOR-INDUCIBLE LARGE EXTERNAL GLYCOPROTEIN (now NEURAL CELL ADHESION MOLECULE L1) was indexed under MEMBRANE GLYCOPROTEINS 1988-2002 & GLYCOPROTEINS 1983-1987; NEURAL CELL ADHESION MOLECULE L1; F11 GLYCOPROTEIN; CELL ADHESION MOLECULE L1; CAML1 GENE PRODUCT; CELL SURFACE GLYCOPROTEIN L1; L1 CELL ADHESION MOLECULE; L1 CAM & NEURAL ADHESION MOLECULE L1 were indexed under MEMBRANE GLYCOPROTEINS 1992-2002, NEURAL CELL ADHESION MOLECULES 1996-2002, CELL ADHESION MOLECULES, NEURONAL 1992-1995 & ANTIGENS, SURFACE 1984-1991; CALL PROTEIN was indexed under MEMBRANE GLYCOPROTEINS 1999-2002 & NEURAL CELL ADHESION MOLECULES 1999-2002; NILE PROTEIN was indexed under MEMBRANE GLYCOPROTEINS 1992-2002 & NEURAL CELL ADHESION MOLECULES 1996-2002
History Note: 2003; use NEURAL CELL ADHESION MOLECULE L1 (NM) 1983-2002; for NEURAL CELL ADHESION MOLECULE L1; F11 GLYCOPROTEIN; CELL ADHESION MOLECULE L1; CAML1 GENE PRODUCT; CELL SURFACE GLYCOPROTEIN L1; L1 CELL ADHESION MOLECULE; L1 CAM & NEURAL ADHESION MOLECULE L1 use LEUKOCYTE L1 ANTIGEN COMPLEX (NM) 1992-2002; for CALL PROTEIN use LEUKOCYTE L1 ANTIGEN COMPLEX (NM) 1999-2002; for NILE PROTEIN use LEUCKCYTE L1 ANTIGEN COMPLEX (NM) 1996-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - Cell Adhesion Molecules [D09.400.430.890.200]
        
        Cell Adhesion Molecules, Neuronal [D09.400.430.890.200.250]
        
        Neural Cell Adhesion Molecules [D09.400.430.890.200.250.520]
        
        CD56 Antigen [D09.400.430.890.200.250.520.156]
        
        Neural Cell Adhesion Molecule L1 [D09.400.430.890.200.250.520.578]
        
        Neurocan [D09.400.430.890.200.250.520.789]
        
        Neuroligins [D09.400.430.890.200.250.520.894]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - Cell Adhesion Molecules [D12.776.395.550.200]
        
        Cell Adhesion Molecules, Neuronal [D12.776.395.550.200.250]
        
        Neural Cell Adhesion Molecules [D12.776.395.550.200.250.520]
        
        CD56 Antigen [D12.776.395.550.200.250.520.156]
        
        Neural Cell Adhesion Molecule L1 [D12.776.395.550.200.250.520.578]
        
        Neurocan [D12.776.395.550.200.250.520.789]
        
        Neuroligins [D12.776.395.550.200.250.520.894]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Cell Adhesion Molecules [D12.776.543.550.200]
        
        Cell Adhesion Molecules, Neuronal [D12.776.543.550.200.250]
        
        Neural Cell Adhesion Molecules [D12.776.543.550.200.250.520]
        
        CD56 Antigen [D12.776.543.550.200.250.520.156]
        
        Neural Cell Adhesion Molecule L1 [D12.776.543.550.200.250.520.578]
        
        Neurocan [D12.776.543.550.200.250.520.789]
        
        Neuroligins [D12.776.543.550.200.250.520.894]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Cell Adhesion Molecules [D23.050.301.350]
      - Cell Adhesion Molecules, Neuronal [D23.050.301.350.250]
        
        Neural Cell Adhesion Molecules [D23.050.301.350.250.520]
        
        CD56 Antigen [D23.050.301.350.250.520.156]
        
        Neural Cell Adhesion Molecule L1 [D23.050.301.350.250.520.578]
        
        Neurocan [D23.050.301.350.250.520.789]
        
        Neuroligins [D23.050.301.350.250.520.894]

Neural Cell Adhesion Molecule L1 Preferred

Concept UI: M0122500
Scope Note: A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
Terms: Neural Cell Adhesion Molecule L1 Preferred Term
Term UI T152505
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); NILE Glycoprotein
Term UI T143115
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Nerve Growth Factor-Inducible Large External Glycoprotein
Term UI T143116
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); CALL Protein
Term UI T152479
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); CamL1 Gene Product
Term UI T152480
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); F11 Glycoprotein
Term UI T152481
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); NGF-Inducible Glycoprotein
Term UI T143114
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); L1CAM
Term UI T152490
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2003); NILE Protein
Term UI T152492
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); Cell Adhesion Molecule L1
Term UI T152496
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); Cell Surface Glycoprotein L1
Term UI T152497
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); Neural Adhesion Molecule L1
Term UI T152504
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); L1 Cell Adhesion Molecule
Term UI T152485
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003)

Neural Cell Adhesion Molecule L1 MeSH Descriptor Data 2025