MeSH Browser

MeSH Heading: Aryldialkylphosphatase
Tree Number(s): D08.811.277.352.660.500
Unique ID: D043303
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D043303
Annotation: entry terms PARAOXONASE-1, and PARAOXONASE-2 see SCR for organism specific terms
Scope Note: An enzyme which catalyzes the hydrolysis of an aryl-dialkyl phosphate to form dialkyl phosphate and an aryl alcohol. It can hydrolyze a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. It may also mediate an enzymatic protection of LOW DENSITY LIPOPROTEINS against oxidative modification and the consequent series of events leading to ATHEROMA formation. The enzyme was previously regarded to be identical with Arylesterase (EC 3.1.1.2).
Entry Term(s): Aryl-dialkyl Phosphatase; Arylalkylphosphatase; Homocysteine Thiolactone Hydrolase; OPA Anhydrase; OPH Enzyme; Organophosphorus Acid Anhydrase; Organophosphorus Acid Anhydrolase; Organophosphorus Acid Hydrolase; Organophosphorus Hydrolase; Paraoxonase; Paraoxonase-1; Paraoxonase-2
Registry Numbers: EC 3.1.8.1; EC 3.1.8.1; EC 3.1.8.1
Related Numbers: EC 3.1.8.1
Previous Indexing: Esterases (1980-2003)
Public MeSH Note: 2004; ARYLDIALKYLPHOSPHATASE was indexed under ESTERASES 1994-2003; PHOSPHORIC MONOESTER HYRDOLASES 1990-1993; PHOSPHOMONOESTERASES 1982-1989
History Note: 2004; use ARYLDIALKYLPHOSPHATASE (NM) 1980 - 2003
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 1955/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Triester Hydrolases [D08.811.277.352.660]
        
        Aryldialkylphosphatase [D08.811.277.352.660.500]

Aryldialkylphosphatase Preferred

Concept UI: M0080022
Registry Numbers: EC 3.1.8.1
Related Numbers: EC 3.1.8.1
Scope Note: An enzyme which catalyzes the hydrolysis of an aryl-dialkyl phosphate to form dialkyl phosphate and an aryl alcohol. It can hydrolyze a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. It may also mediate an enzymatic protection of LOW DENSITY LIPOPROTEINS against oxidative modification and the consequent series of events leading to ATHEROMA formation. The enzyme was previously regarded to be identical with Arylesterase (EC 3.1.1.2).
Terms: Aryldialkylphosphatase Preferred Term
Term UI T110025
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Aryl-dialkyl Phosphatase
Term UI T426474
Date10/12/2000
LexicalTag NON
ThesaurusID NLM (2004); Arylalkylphosphatase
Term UI T426475
Date10/12/2000
LexicalTag NON
ThesaurusID NLM (2004); Homocysteine Thiolactone Hydrolase
Term UI T409043
Date03/11/2000
LexicalTag NON
ThesaurusID NLM (2004); OPA Anhydrase
Term UI T426473
Date10/12/2000
LexicalTag ABX
ThesaurusID NLM (2004); OPH Enzyme
Term UI T426479
Date10/12/2000
LexicalTag ABX
ThesaurusID NLM (2004); Organophosphorus Acid Anhydrase
Term UI T426476
Date10/12/2000
LexicalTag NON
ThesaurusID NLM (2004); Organophosphorus Acid Anhydrolase
Term UI T426472
Date10/12/2000
LexicalTag NON
ThesaurusID NLM (2004); Organophosphorus Acid Hydrolase
Term UI T426477
Date10/12/2000
LexicalTag NON
ThesaurusID NLM (2004); Organophosphorus Hydrolase
Term UI T426478
Date10/12/2000
LexicalTag NON
ThesaurusID NLM (2004); Paraoxonase
Term UI T110020
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004)

Paraoxonase-1 Narrower

Paraoxonase-2 Narrower

Aryldialkylphosphatase MeSH Descriptor Data 2024