MeSH Browser

MeSH Heading: Leukemia, Large Granular Lymphocytic
Tree Number(s): C04.557.337.428.580.049; C15.378.508.428.580.049; C15.604.515.560.575.049; C20.683.515.528.582.049
Unique ID: D054066
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054066
Scope Note: A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.
Entry Term(s): Aggressive NK Cell Leukemia; Aggressive Natural Killer Cell Leukemia; LGL Leukemia; Large Granular Lymphocyte Leukemia; Large Granular Lymphocytosis; Leukemia, LGL; Leukemia, Lymphocytic, Large Granular; Leukemia, NK-LGL; Leukemia, Natural Killer Cell Large Granular Lymphocytic; Leukemia, T-Cell Large Granular Lymphocytic; Leukemia, T-LGL; Lymphoproliferative Disease of Granular Lymphocytes; Lymphoproliferative Disease of Large Granular Lymphocytes; NK-Cell Large Granular Lymphocytic Leukemia; NK-LGL Leukemia; Natural Killer Cell Large Granular Lymphocytic Leukemia; T-Cell Large Granular Lymphocyte Leukemia; T-Cell Large Granular Lymphocytic Leukemia; T-LGL Leukemia
Previous Indexing: Leukemia, Lymphocytic (1987-2007)
See Also: Lymphocytosis
Public MeSH Note: 2008; see LEUKEMIA, LYMPHOCYTIC 1997-2007
History Note: 2008; use LEUKEMIA, LYMPHOCYTIC 1997-2007
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2023/05/31

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Neoplasms [C04]
- Neoplasms by Histologic Type [C04.557]
  - Leukemia [C04.557.337]
    - Leukemia, Lymphoid [C04.557.337.428]
      - Leukemia, T-Cell [C04.557.337.428.580]
        
        Leukemia, Large Granular Lymphocytic [C04.557.337.428.580.049]
        
        Leukemia, Prolymphocytic, T-Cell [C04.557.337.428.580.075]
        
        Leukemia-Lymphoma, Adult T-Cell [C04.557.337.428.580.100]

Hemic and Lymphatic Diseases [C15]
- Hematologic Diseases [C15.378]
  - Leukemia [C15.378.508]
    - Leukemia, Lymphoid [C15.378.508.428]
      - Leukemia, T-Cell [C15.378.508.428.580]
        
        Leukemia, Large Granular Lymphocytic [C15.378.508.428.580.049]
        
        Leukemia, Prolymphocytic, T-Cell [C15.378.508.428.580.075]
        
        Leukemia-Lymphoma, Adult T-Cell [C15.378.508.428.580.100]

Hemic and Lymphatic Diseases [C15]
- Lymphatic Diseases [C15.604]
  - Lymphoproliferative Disorders [C15.604.515]
    - Leukemia, Lymphoid [C15.604.515.560]
      - Leukemia, T-Cell [C15.604.515.560.575]
        
        Leukemia, Large Granular Lymphocytic [C15.604.515.560.575.049]
        
        Leukemia-Lymphoma, Adult T-Cell [C15.604.515.560.575.100]
        
        Leukemia, Prolymphocytic, T-Cell [C15.604.515.560.575.125]

Immune System Diseases [C20]
- Immunoproliferative Disorders [C20.683]
  - Lymphoproliferative Disorders [C20.683.515]
    - Leukemia, Lymphoid [C20.683.515.528]
      - Leukemia, T-Cell [C20.683.515.528.582]
        
        Leukemia, Large Granular Lymphocytic [C20.683.515.528.582.049]
        
        Leukemia-Lymphoma, Adult T-Cell [C20.683.515.528.582.100]
        
        Leukemia, Prolymphocytic, T-Cell [C20.683.515.528.582.125]

Leukemia, Large Granular Lymphocytic Preferred

Concept UI: M0012389
Scope Note: A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.
Terms: Leukemia, Large Granular Lymphocytic Preferred Term
Term UI T023665
Date11/02/1995
LexicalTag NON
ThesaurusID NLM (1997); Aggressive NK Cell Leukemia
Term UI T000880185
Date05/21/2015
LexicalTag ABX
ThesaurusID NLM (2016); Leukemia, Lymphocytic, Large Granular
Term UI T023666
Date11/02/1995
LexicalTag NON
ThesaurusID NLM (1997); Lymphoproliferative Disease of Granular Lymphocytes
Term UI T679702
Date08/15/2006
LexicalTag NON
ThesaurusID NLM (2008); LGL Leukemia
Term UI T679703
Date08/15/2006
LexicalTag ACX
ThesaurusID; Lymphoproliferative Disease of Large Granular Lymphocytes
Term UI T679710
Date08/15/2006
LexicalTag NON
ThesaurusID NLM (2008); Leukemia, LGL
Term UI T679711
Date08/15/2006
LexicalTag ACX
ThesaurusID NLM (2008); Aggressive Natural Killer Cell Leukemia
Term UI T000879213
Date05/05/2015
LexicalTag NON
ThesaurusID NLM (2016); Large Granular Lymphocyte Leukemia
Term UI T749769
Date04/22/2009
LexicalTag NON
ThesaurusID

Leukemia, T-Cell Large Granular Lymphocytic Narrower

Leukemia, Natural Killer Cell Large Granular Lymphocytic Narrower

Leukemia, Large Granular Lymphocytic MeSH Descriptor Data 2025