MeSH Browser

MeSH Heading: Lissencephaly
Tree Number(s): C10.500.507.450.499; C16.131.666.507.450.499
Unique ID: D054082
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054082
Annotation: note specifics; MICROLISSENCEPHALY see MICROCEPHALY is also available
Scope Note: A smooth brain malformation of the CEREBRAL CORTEX resulting from the abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex.
Entry Term(s): Agyria; Broad Gyri of Cerebrum; Large Gyri of Cerebrum; Lissencephalia; Macrogyria; Pachygyria
Public MeSH Note: 2008
History Note: 2008
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2016/02/26

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Lissencephaly MeSH Descriptor Data 2025