MeSH Browser

MeSH Heading: Central Tolerance
Tree Number(s): G12.535.425.800.200
Unique ID: D061167
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D061167
Scope Note: The mechanism, in central lymphoid organs (THYMUS; BONE MARROW), that prevents immature lymphocytes from reacting to SELF-ANTIGENS. This is accomplished by CLONAL ANERGY and CLONAL DELETION.
Previous Indexing: Immune Tolerance (1980-2011); Self Tolerance (1998-2011)
Public MeSH Note: 2012
History Note: 2012
Date Established: 2012/01/01
Date of Entry: 2011/06/24
Revision Date: 2016/06/16

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Central Tolerance MeSH Descriptor Data 2025