MeSH Browser

MeSH Heading: Aurora Kinase A
Tree Number(s): D08.811.913.696.620.682.700.103.500; D12.776.167.049.500; D12.776.476.563.103.500
Unique ID: D064096
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D064096
Scope Note: An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. Aurora A overexpression in many malignant tumor types suggests that it may be directly involved in NEOPLASTIC CELL TRANSFORMATION.
Entry Term(s): AURKA; AURORA2 Protein; Aurora A Kinase; Aurora A Kinases; Aurora Kinases A; Aurora-A Kinase; AuroraA Kinase; BTAK Protein; Breast-Tumor-Amplified Kinase; STK15 Kinase; Serine-Threonine Protein Kinase 15
Registry Number: EC 2.7.11.1
Public MeSH Note: 2014; was indexed under PROTEIN SERINE-THREONINE KINASES 1995-2013
History Note: 2014
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2021/05/20

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Aurora Kinases [D08.811.913.696.620.682.700.103]
        
        Aurora Kinase A [D08.811.913.696.620.682.700.103.500]
        
        Aurora Kinase B [D08.811.913.696.620.682.700.103.750]
        
        Aurora Kinase C [D08.811.913.696.620.682.700.103.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Cell Cycle Proteins [D12.776.167]
    - Aurora Kinases [D12.776.167.049]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - Aurora Kinases [D12.776.476.563.103]
        
        Aurora Kinase A [D12.776.476.563.103.500]
        
        Aurora Kinase B [D12.776.476.563.103.750]
        
        Aurora Kinase C [D12.776.476.563.103.875]

Aurora Kinase A Preferred

Concept UI: M0579611
Registry Number: EC 2.7.11.1
Scope Note: An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. Aurora A overexpression in many malignant tumor types suggests that it may be directly involved in NEOPLASTIC CELL TRANSFORMATION.
Terms: Aurora Kinase A Preferred Term
Term UI T834637
Date12/20/2012
LexicalTag NON
ThesaurusID NLM (2005); Aurora A Kinases
Term UI T834622
Date12/20/2012
LexicalTag NON
ThesaurusID NLM (2014); AURKA
Term UI T834623
Date12/20/2012
LexicalTag ABB
ThesaurusID NLM (2014); Aurora A Kinase
Term UI T834636
Date12/20/2012
LexicalTag NON
ThesaurusID NLM (2004); Serine-Threonine Protein Kinase 15
Term UI T836389
Date01/28/2013
LexicalTag NON
ThesaurusID NLM (2014); AURORA2 Protein
Term UI T834640
Date12/20/2012
LexicalTag ABX
ThesaurusID NLM (2005); AuroraA Kinase
Term UI T834641
Date12/20/2012
LexicalTag NON
ThesaurusID NLM (2001); Breast-Tumor-Amplified Kinase
Term UI T834642
Date12/20/2012
LexicalTag NON
ThesaurusID NLM (2005); BTAK Protein
Term UI T834643
Date12/20/2012
LexicalTag ABX
ThesaurusID NLM (2000); STK15 Kinase
Term UI T834645
Date12/20/2012
LexicalTag NON
ThesaurusID NLM (2000); Aurora Kinases A
Term UI T834359
Date12/14/2012
LexicalTag NON
ThesaurusID NLM (2014); Aurora-A Kinase
Term UI T834639
Date12/20/2012
LexicalTag NON
ThesaurusID NLM (2004)

Aurora Kinase A MeSH Descriptor Data 2023