MeSH Browser

MeSH Heading: HIV Envelope Protein gp120
Tree Number(s): D12.776.964.350.520.350; D12.776.964.775.325.164.249; D12.776.964.775.562.500.500; D12.776.964.970.880.325.164.249; D23.050.327.520.350
Unique ID: D015699
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015699
Scope Note: External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.
Entry Term(s): Envelope Glycoprotein gp120, HIV; HIV Envelope Glycoprotein gp120; HTLV-III gp120; env Protein gp120, HIV; gp120 Envelope Glycoprotein, HIV; gp120(HIV)
Registry Numbers: 0
NLM Classification #: WC 503
Previous Indexing: Retroviridae Proteins (1986-1989); Viral Envelope Proteins (1983-1989)
See Also: Peptide T
Public MeSH Note: 90
History Note: 90
Date Established: 1990/01/01
Date of Entry: 1989/06/19
Revision Date: 2022/04/13

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0024082
Registry Numbers: 0
Scope Note: External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.
Terms: HIV Envelope Protein gp120 Preferred Term
Term UI T046535
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1990); gp120(HIV)
Term UI T046534
Date05/25/1989
LexicalTag NON
ThesaurusID NLM (1990); Envelope Glycoprotein gp120, HIV
Term UI T046533
Date02/14/1989
LexicalTag NON
ThesaurusID NLM (1990); env Protein gp120, HIV
Term UI T046530
Date06/19/1989
LexicalTag NON
ThesaurusID NLM (1990); gp120 Envelope Glycoprotein, HIV
Term UI T046531
Date02/14/1989
LexicalTag NON
ThesaurusID NLM (1990); HIV Envelope Glycoprotein gp120
Term UI T046532
Date02/14/1989
LexicalTag NON
ThesaurusID NLM (1990); HTLV-III gp120
Term UI T046536
Date02/14/1989
LexicalTag NON
ThesaurusID NLM (1990)

HIV Envelope Protein gp120 MeSH Descriptor Data 2024