MeSH Browser

MeSH Heading: ELAV-Like Protein 1
Tree Number(s): D12.776.157.725.813.500.250; D12.776.664.962.813.500.250
Unique ID: D000067780
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000067780
Scope Note: An RRM protein that binds to the 3'-UTR region of mRNAs and increases their stability. In EMBRYONIC STEM CELLS, it binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs and preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), to stabilize them and promote differentiation.
Entry Term(s): ELAVL1 protein; HuR Antigen; HuR Paraneoplastic Encephalomyelitis Antigen; HuR Protein
Registry Number: 0
Previous Indexing: ELAV Proteins (2005-2015); RNA-Binding Proteins (2000-2015)
Public MeSH Note: 2016; see HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS 2012-2015
History Note: 2016; use ELAV PROTEINS 2012-2015
Date Established: 2016/01/01
Date of Entry: 2015/07/10
Revision Date: 2015/07/10

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0553966
Registry Number: 0
Scope Note: An RRM protein that binds to the 3'-UTR region of mRNAs and increases their stability. In EMBRYONIC STEM CELLS, it binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs and preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), to stabilize them and promote differentiation.
Terms: ELAV-Like Protein 1 Preferred Term
Term UI T784545
Date01/25/2011
LexicalTag ABX
ThesaurusID NLM (2012); HuR Paraneoplastic Encephalomyelitis Antigen
Term UI T000875899
Date02/26/2015
LexicalTag ABX
ThesaurusID NLM (2016); HuR Protein
Term UI T784544
Date01/25/2011
LexicalTag ABX
ThesaurusID NLM (2012); ELAVL1 protein
Term UI T000873539
Date01/13/2015
LexicalTag ABX
ThesaurusID NLM (2016); HuR Antigen
Term UI T784543
Date01/25/2011
LexicalTag ABX
ThesaurusID NLM (2012)

ELAV-Like Protein 1 MeSH Descriptor Data 2023