MeSH Browser

MeSH Heading: Pharmacogenomic Variants
Tree Number(s): G05.365.795.446
Unique ID: D000071184
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071184
Scope Note: Naturally occurring genetic variations associated with drug response (e.g., dosage, extent and rate of metabolic processes). While these variants are not markers for GENETIC PREDISPOSITION TO DISEASE they influence PHARMACOKINETICS and pharmacodynamics and often occur on genes encoding drug metabolism enzymes and transporters (e.g., ANGIOTENSIN CONVERTING ENZYME; CYTOCHROME P-450 CYP2D6).
Entry Term(s): Pharmacogenetic Variants; Pharmacokinetic Genetic Variants
Previous Indexing: Genetic Variation (1968-2016); Pharmacogenetics (1968-2016); Polymorphism, Genetic (1980-2016)
See Also: Pharmacogenetics; Precision Medicine
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/01/20

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M000613458
Scope Note: Naturally occurring genetic variations associated with drug response (e.g., dosage, extent and rate of metabolic processes). While these variants are not markers for GENETIC PREDISPOSITION TO DISEASE they influence PHARMACOKINETICS and pharmacodynamics and often occur on genes encoding drug metabolism enzymes and transporters (e.g., ANGIOTENSIN CONVERTING ENZYME; CYTOCHROME P-450 CYP2D6).
Terms: Pharmacogenomic Variants Preferred Term
Term UI T000893450
Date01/11/2016
LexicalTag NON
ThesaurusID NLM (2017); Pharmacokinetic Genetic Variants
Term UI T000893452
Date01/11/2016
LexicalTag NON
ThesaurusID NLM (2017); Pharmacogenetic Variants
Term UI T000893451
Date01/11/2016
LexicalTag NON
ThesaurusID NLM (2017)

Pharmacogenomic Variants MeSH Descriptor Data 2025