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Cytochrome P-450 CYP2D6 MeSH Descriptor Data 2022


MeSH Heading
Cytochrome P-450 CYP2D6
Tree Number(s)
D08.244.453.005.600
D08.244.453.491.372
D08.811.682.690.708.170.010.600
D08.811.682.690.708.170.450.368
D12.776.422.220.453.010.600
D12.776.422.220.453.491.368
Unique ID
D019389
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019389
Scope Note
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.
Entry Term(s)
CYP 2D6
CYP2D6
Cytochrome P450 2D6
Debrisoquine 4-Hydroxylase
Debrisoquine 4-Monooxygenase
Debrisoquine Hydroxylase
Imipramine 2-Hydroxylase
Sparteine Monooxygenase
Registry Number
EC 1.14.14.1
Previous Indexing
Cytochrome P-450 (1975-1996)
Hydroxylases (1979-1996)
Public MeSH Note
97; DEBRISOQUINE 4-HYDROXYLASE was indexed under CYTOCHROME P-450 & HYDROXYLASES 1982-96
Online Note
use CYTOCHROME P-450 CYP2D6 (NM) to search DEBRISOQUINE 4-HYDROXYLASE 1982-96
History Note
97; was DEBRISOQUINE 4-HYDROXYLASE (NM) 1982-96
Entry Combination
antagonists & inhibitors:Cytochrome P-450 CYP2D6 Inhibitors
Date Established
1997/01/01
Date of Entry
1996/06/13
Revision Date
2016/05/27
Cytochrome P-450 CYP2D6 Preferred
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