MeSH Browser

MeSH Heading: Cytochrome P-450 CYP2B1
Tree Number(s): D08.244.453.005.550; D08.244.453.491.313; D08.811.682.690.708.170.010.550; D08.811.682.690.708.170.450.313; D12.776.422.220.453.010.550; D12.776.422.220.453.491.313
Unique ID: D019362
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019362
Annotation: do not confuse with other cytochrome P-450 CYP's
Scope Note: A major cytochrome P-450 enzyme which is inducible by PHENOBARBITAL in both the LIVER and SMALL INTESTINE. It is active in the metabolism of compounds like pentoxyresorufin, TESTOSTERONE, and ANDROSTENEDIONE. This enzyme, encoded by CYP2B1 gene, also mediates the activation of CYCLOPHOSPHAMIDE and IFOSFAMIDE to MUTAGENS.
Entry Term(s): 7-Benzyloxyresorufin O-Dealkylase; 7-Pentylresorufin O-Depentylase; BROD; Benzyloxyresorufin O-Dealkylase; CYP 2B1; CYP2B1; Cytochrome P450 2B1; PROD; Pentoxyresorufin O-Dealkylase
Previous Indexing: Cytochrome P-450 (1985-1996); Oxidoreductases (1985-1996)
Public MeSH Note: 97; PENTOXYRESORUFIN O-DEALKYLASE was indexed under CYTOCHROME P-450 & OXIDOREDUCTASES 1985-96
Online Note: use CYTOCHROME P-450 CYP2B1 (NM) to search PENTOXYRESORUFIN O-DEALKYLASE 1985-96
History Note: 97; was PENTOXYRESORUFIN O-DEALKYLASE (NM) 1985-96
Date Established: 1997/01/01
Date of Entry: 1996/06/13
Revision Date: 2016/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0028816
Scope Note: A major cytochrome P-450 enzyme which is inducible by PHENOBARBITAL in both the LIVER and SMALL INTESTINE. It is active in the metabolism of compounds like pentoxyresorufin, TESTOSTERONE, and ANDROSTENEDIONE. This enzyme, encoded by CYP2B1 gene, also mediates the activation of CYCLOPHOSPHAMIDE and IFOSFAMIDE to MUTAGENS.
Terms: Cytochrome P-450 CYP2B1 Preferred Term
Term UI T057699
Date01/01/1999
LexicalTag ABX
ThesaurusID NLM (1997); 7-Benzyloxyresorufin O-Dealkylase
Term UI T057695
Date02/16/1996
LexicalTag NON
ThesaurusID NLM (1997); PROD
Term UI T057696
Date01/26/1996
LexicalTag ABB
ThesaurusID NLM (1997); CYP 2B1
Term UI T057697
Date02/07/1996
LexicalTag ABB
ThesaurusID NLM (1997); Cytochrome P450 2B1
Term UI T057698
Date03/13/1996
LexicalTag NON
ThesaurusID NLM (1997); 7-Pentylresorufin O-Depentylase
Term UI T057700
Date02/07/1996
LexicalTag NON
ThesaurusID NLM (1997); Benzyloxyresorufin O-Dealkylase
Term UI T057701
Date04/25/1996
LexicalTag NON
ThesaurusID NLM (1997); CYP2B1
Term UI T057702
Date01/26/1996
LexicalTag ABB
ThesaurusID NLM (1997); Pentoxyresorufin O-Dealkylase
Term UI T057694
Date02/07/1996
LexicalTag NON
ThesaurusID NLM (1997); BROD
Term UI T057703
Date01/26/1996
LexicalTag ABB
ThesaurusID NLM (1997)

Cytochrome P-450 CYP2B1 MeSH Descriptor Data 2025