Cytochrome P-450 CYP2B6 MeSH Descriptor Data 2025

MeSH Heading: Cytochrome P-450 CYP2B6
Tree Number(s): D08.244.453.005.575; D08.244.453.491.344; D08.811.682.690.708.170.010.575; D08.811.682.690.708.170.450.344; D12.776.422.220.453.010.575; D12.776.422.220.453.491.344
Unique ID: D065702
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D065702
Scope Note: A cytochrome P450 enzyme subtype that oxidizes a diverse array of XENOBIOTICS. The expression of CYP2B6 varies widely between individuals which is due to the high rate of GENETIC POLYMORPHISMS. Examples of drugs metabolized by CYP2B6 include BUPROPION; efavirenz; CYCLOPHOSPHAMIDE; and MEPERIDINE.
Entry Term(s): 1,4-Cineole 2-exo-Monooxygenase; CYP2B6; CYPIIB6; Cytochrome P450 2B6
Public MeSH Note: 2015; CYTOCHROME P-450 CYP2B6 was indexed under ARYL HYDROCARBON HYDROXYLASES 1997-2014
History Note: 2015
Entry Combination: antagonists & inhibitors:Cytochrome P-450 CYP2B6 Inhibitors
Date Established: 2015/01/01
Date of Entry: 2014/06/26
Revision Date: 2016/05/27

Entry Combination: antagonists & inhibitors:Cytochrome P-450 CYP2B6 Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Aryl Hydrocarbon Hydroxylases [D08.244.453.005]

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Cytochrome P450 Family 2 [D08.244.453.491]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Aryl Hydrocarbon Hydroxylases [D08.811.682.690.708.170.010]
        
        7-Alkoxycoumarin O-Dealkylase [D08.811.682.690.708.170.010.024]
        
        Aniline Hydroxylase [D08.811.682.690.708.170.010.050]
        
        Benzopyrene Hydroxylase [D08.811.682.690.708.170.010.110]
        
        Cytochrome P-450 CYP1A1 [D08.811.682.690.708.170.010.277]
        
        Cytochrome P-450 CYP1A2 [D08.811.682.690.708.170.010.443]
        
        Cytochrome P-450 CYP1B1 [D08.811.682.690.708.170.010.500]
        
        Cytochrome P-450 CYP2B1 [D08.811.682.690.708.170.010.550]
        
        Cytochrome P-450 CYP2B6 [D08.811.682.690.708.170.010.575]
        
        Cytochrome P-450 CYP2C8 [D08.811.682.690.708.170.010.590]
        
        Cytochrome P-450 CYP2D6 [D08.811.682.690.708.170.010.600]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P450 Family 2 [D08.811.682.690.708.170.450]
        
        Cytochrome P-450 CYP2A6 [D08.811.682.690.708.170.450.250]
        
        Cytochrome P-450 CYP2B1 [D08.811.682.690.708.170.450.313]
        
        Cytochrome P-450 CYP2B6 [D08.811.682.690.708.170.450.344]
        
        Cytochrome P-450 CYP2C8 [D08.811.682.690.708.170.450.360]
        
        Cytochrome P-450 CYP2D6 [D08.811.682.690.708.170.450.368]
        
        Cytochrome P-450 CYP2E1 [D08.811.682.690.708.170.450.375]
        
        Limonene Hydroxylases [D08.811.682.690.708.170.450.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Aryl Hydrocarbon Hydroxylases [D12.776.422.220.453.010]
        
        Aniline Hydroxylase [D12.776.422.220.453.010.050]
        
        Benzopyrene Hydroxylase [D12.776.422.220.453.010.110]
        
        Cytochrome P-450 CYP1A1 [D12.776.422.220.453.010.332]
        
        Cytochrome P-450 CYP1A2 [D12.776.422.220.453.010.443]
        
        Cytochrome P-450 CYP1B1 [D12.776.422.220.453.010.500]
        
        Cytochrome P-450 CYP2B1 [D12.776.422.220.453.010.550]
        
        Cytochrome P-450 CYP2B6 [D12.776.422.220.453.010.575]
        
        Cytochrome P-450 CYP2C8 [D12.776.422.220.453.010.590]
        
        Cytochrome P-450 CYP2D6 [D12.776.422.220.453.010.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P450 Family 2 [D12.776.422.220.453.491]
        
        Cytochrome P-450 CYP2A6 [D12.776.422.220.453.491.250]
        
        Cytochrome P-450 CYP2B1 [D12.776.422.220.453.491.313]
        
        Cytochrome P-450 CYP2B6 [D12.776.422.220.453.491.344]
        
        Cytochrome P-450 CYP2C8 [D12.776.422.220.453.491.360]
        
        Cytochrome P-450 CYP2D6 [D12.776.422.220.453.491.368]
        
        Cytochrome P-450 CYP2E1 [D12.776.422.220.453.491.375]
        
        Limonene Hydroxylases [D12.776.422.220.453.491.500]

Cytochrome P-450 CYP2B6 Preferred

Concept UI: M0590403
Scope Note: A cytochrome P450 enzyme subtype that oxidizes a diverse array of XENOBIOTICS. The expression of CYP2B6 varies widely between individuals which is due to the high rate of GENETIC POLYMORPHISMS. Examples of drugs metabolized by CYP2B6 include BUPROPION; efavirenz; CYCLOPHOSPHAMIDE; and MEPERIDINE.
Terms: Cytochrome P-450 CYP2B6 Preferred Term
Term UI T853511
Date01/13/2014
LexicalTag ABX
ThesaurusID NLM (2015); CYP2B6
Term UI T300758
Date01/01/1955
LexicalTag ABB
ThesaurusID NLM (1997); CYPIIB6
Term UI T505176
Date07/19/2002
LexicalTag ABX
ThesaurusID NLM (2002); Cytochrome P450 2B6
Term UI T853513
Date01/13/2014
LexicalTag ABX
ThesaurusID NLM (2015); 1,4-Cineole 2-exo-Monooxygenase
Term UI T853680
Date01/16/2014
LexicalTag NON
ThesaurusID NLM (2015)

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