- Concept UI
- M0005591
- Registry Numbers
- 9035-51-2
- Scope Note
- A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
- Terms
-
Cytochrome P-450 Enzyme System
Preferred Term
Term UI
T485421
Date03/12/2002
LexicalTag
NON
ThesaurusID
NLM (2003)
-
P-450 Enzyme
Term UI
T000997454
Date11/19/2019
LexicalTag
NON
ThesaurusID
NLM (2021)
-
P450 Enzyme
Term UI
T000997451
Date11/19/2019
LexicalTag
NON
ThesaurusID
NLM (2021)
-
Cytochrome P-450
Term UI
T010407
Date01/01/1999
LexicalTag
NON
ThesaurusID
NLM (1973)
-
Cytochrome P450
Term UI
T010408
Date12/07/1977
LexicalTag
NON
ThesaurusID
UNK (19XX)
-
P-450 Enzymes
Term UI
T852909
Date01/03/2014
LexicalTag
NON
ThesaurusID
NLM (2015)
-
P450 Enzymes
Term UI
T852910
Date01/03/2014
LexicalTag
NON
ThesaurusID
NLM (2015)
-
Cytochrome P-450 Enzymes
Term UI
T854676
Date02/05/2014
LexicalTag
NON
ThesaurusID
NLM (2015)
-
Cytochrome P450 Superfamily
Term UI
T000899532
Date04/22/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
Cytochrome P-450 Superfamily
Term UI
T000899533
Date04/22/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
Cytochrome p450 Families
Term UI
T000899534
Date04/22/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
Cytochrome P-450 Families
Term UI
T000899535
Date04/22/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
CYP450 Superfamily
Term UI
T000899536
Date04/22/2016
LexicalTag
ABX
ThesaurusID
NLM (2017)
-
Cytochrome P-450 Enzyme
Term UI
T000997453
Date11/19/2019
LexicalTag
NON
ThesaurusID
NLM (2021)
-
CYP450 Family
Term UI
T000899537
Date04/22/2016
LexicalTag
ABX
ThesaurusID
NLM (2017)