MeSH Browser

MeSH Heading: Prolyl Hydroxylases
Tree Number(s): D08.811.682.690.416.617; D08.811.682.690.708.694
Unique ID: D064828
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D064828
Scope Note: Enzymes that specifically hydroxylate PROLINE residues on proteins.
Entry Term(s): Peptidyl Prolyl Hydroxylase; Proline Hydroxylase; Proline,2-Oxoglutarate 4-Dioxygenase; Prolyl 4-Hydroxylase; Prolyl Hydroxylase
Registry Numbers: EC 1.14.11.-
Public MeSH Note: 2014; for PROLYL 4-HYDROXYLASE see PROCOLLAGEN-PROLINE DIOXYGENASE 1983-2013; for PEPTIDYL PROLYL HYDROXYLASE see PROCOLLAGEN-PROLINE DIOXYGENASE 1985-2013; for PROLINE,2-OXOGLUTARATE 4-DIOXYGENASE see PROCOLLAGEN-PROLINE DIOXYGENASE 1977-2013; for PROLINE HYDROXYLASE see PROCOLLAGEN-PROLINE DIOXYGENASE 1993-2013; for PROLYL HYDROXYLASE see PROCOLLAGEN-PROLINE DIOXYGENASE 1982-2013
History Note: 2014; for PROLYL 4-HYDROXYLASE use PROCOLLAGEN-PROLINE DIOXYGENASE 1983-2013; for PEPTIDYL PROLYL HYDROXYLASE use PROCOLLAGEN-PROLINE DIOXYGENASE 1985-2013; for PROLINE,2-OXOGLUTARATE 4-DIOXYGENASE use PROCOLLAGEN-PROLINE DIOXYGENASE 1977-2013; for PROLINE HYDROXYLASE use PROCOLLAGEN-PROLINE DIOXYGENASE 1993-2013; for PROLYL HYDROXYLASE use PROCOLLAGEN-PROLINE DIOXYGENASE 1982-2013
Entry Combination: antagonists & inhibitors:Prolyl-Hydroxylase Inhibitors
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 1955/01/01

Entry Combination: antagonists & inhibitors:Prolyl-Hydroxylase Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Dioxygenases [D08.811.682.690.416]
        
        AlkB Enzymes [D08.811.682.690.416.139]
        
        Catechol 1,2-Dioxygenase [D08.811.682.690.416.277]
        
        Catechol 2,3-Dioxygenase [D08.811.682.690.416.305]
        
        Cysteine Dioxygenase [D08.811.682.690.416.319]
        
        Homogentisate 1,2-Dioxygenase [D08.811.682.690.416.326]
        
        3-Hydroxyanthranilate 3,4-Dioxygenase [D08.811.682.690.416.328]
        
        4-Hydroxyphenylpyruvate Dioxygenase [D08.811.682.690.416.330]
        
        Indoleamine-Pyrrole 2,3,-Dioxygenase [D08.811.682.690.416.333]
        
        Jumonji Domain-Containing Histone Demethylases [D08.811.682.690.416.388]
        
        Lipoxygenases [D08.811.682.690.416.583]
        
        Prolyl Hydroxylases [D08.811.682.690.416.617]
        
        Hypoxia-Inducible Factor-Proline Dioxygenases [D08.811.682.690.416.617.500]
        
        Procollagen-Proline Dioxygenase [D08.811.682.690.416.617.750]
        
        Protocatechuate-3,4-Dioxygenase [D08.811.682.690.416.652]
        
        Tryptophan Oxygenase [D08.811.682.690.416.722]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Benzoate 4-Monooxygenase [D08.811.682.690.708.062]
        
        Catechol Oxidase [D08.811.682.690.708.125]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Dopamine beta-Hydroxylase [D08.811.682.690.708.292]
        
        Fatty Acid Desaturases [D08.811.682.690.708.392]
        
        gamma-Butyrobetaine Dioxygenase [D08.811.682.690.708.401]
        
        Heme Oxygenase (Decyclizing) [D08.811.682.690.708.410]
        
        4-Hydroxybenzoate-3-Monooxygenase [D08.811.682.690.708.425]
        
        Kynurenine 3-Monooxygenase [D08.811.682.690.708.557]
        
        Phenylalanine Hydroxylase [D08.811.682.690.708.601]
        
        Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase [D08.811.682.690.708.660]
        
        Prolyl Hydroxylases [D08.811.682.690.708.694]
        
        Hypoxia-Inducible Factor-Proline Dioxygenases [D08.811.682.690.708.694.500]
        
        Procollagen-Proline Dioxygenase [D08.811.682.690.708.694.750]
        
        Prostaglandin-Endoperoxide Synthases [D08.811.682.690.708.715]
        
        Squalene Monooxygenase [D08.811.682.690.708.749]
        
        Trans-Cinnamate 4-Monooxygenase [D08.811.682.690.708.826]
        
        Tryptophan Hydroxylase [D08.811.682.690.708.870]
        
        Tyrosine 3-Monooxygenase [D08.811.682.690.708.923]
        
        Vitamin K Epoxide Reductases [D08.811.682.690.708.961]

Prolyl Hydroxylases Preferred

Concept UI: M0584347
Registry Numbers: EC 1.14.11.-
Scope Note: Enzymes that specifically hydroxylate PROLINE residues on proteins.
Terms: Prolyl Hydroxylases Preferred Term
Term UI T843395
Date04/30/2013
LexicalTag NON
ThesaurusID NLM (2014); Peptidyl Prolyl Hydroxylase
Term UI T033589
Date10/02/1984
LexicalTag NON
ThesaurusID UNK (19XX); Proline Hydroxylase
Term UI T033591
Date12/18/1992
LexicalTag NON
ThesaurusID NLM (1994); Proline,2-Oxoglutarate 4-Dioxygenase
Term UI T033595
Date05/20/1976
LexicalTag NON
ThesaurusID UNK (19XX); Prolyl 4-Hydroxylase
Term UI T033592
Date12/06/1982
LexicalTag NON
ThesaurusID UNK (19XX); Prolyl Hydroxylase
Term UI T033593
Date04/27/1981
LexicalTag NON
ThesaurusID UNK (19XX)

Prolyl Hydroxylases MeSH Descriptor Data 2025