MeSH Browser

MeSH Heading: Homogentisate 1,2-Dioxygenase
Tree Number(s): D08.811.682.690.416.326
Unique ID: D050560
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050560
Scope Note: A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
Entry Term(s): Homogentisate Dioxygenase; Homogentisate Oxidase; Homogentisate Oxygenase; Homogentisic Acid Oxidase
Related Numbers: 9029-49-6
Previous Indexing: Dioxygenases (1969-2005)
See Also: Alkaptonuria
Public MeSH Note: 2006; HOMOGENTISATE 1,2-DIOXYGENASE was indexed under DIOXYGENASES 1969-2005, OXYGENASES 1983-2004, & under HOMOGENTISIC ACID 1973-1982
History Note: 2006(1969)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2012/07/03

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0076145
Related Numbers: 9029-49-6
Scope Note: A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
Terms: Homogentisate 1,2-Dioxygenase Preferred Term
Term UI T106148
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Homogentisate Dioxygenase
Term UI T620177
Date11/28/2004
LexicalTag NON
ThesaurusID NLM (2006); Homogentisate Oxidase
Term UI T620178
Date11/28/2004
LexicalTag NON
ThesaurusID NLM (2006); Homogentisate Oxygenase
Term UI T106146
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Homogentisic Acid Oxidase
Term UI T106147
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006)

Homogentisate 1,2-Dioxygenase MeSH Descriptor Data 2025