MeSH Browser

MeSH Heading: AlkB Enzymes
Tree Number(s): D08.811.074.062; D08.811.682.690.416.139
Unique ID: D000071496
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071496
Scope Note: A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE).
Entry Term(s): AlkB Homologs; Alkylated DNA Repair Protein AlkB Homologs; Alkylation Repair Homolog Proteins; Alkylation Repair Homologs
Registry Number: EC 1.14.11.33
Previous Indexing: DNA Repair Enzymes (2004-2016); Dioxygenases (2004-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2016/06/28

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - DNA Repair Enzymes [D08.811.074]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Dioxygenases [D08.811.682.690.416]
        
        AlkB Enzymes [D08.811.682.690.416.139]
        
        AlkB Homolog 1, Histone H2a Dioxygenase [D08.811.682.690.416.139.500]
        
        AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase [D08.811.682.690.416.139.750]
        
        AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase [D08.811.682.690.416.139.875]
        
        AlkB Homolog 4, Lysine Demethylase [D08.811.682.690.416.139.937]
        
        AlkB Homolog 5, RNA Demethylase [D08.811.682.690.416.139.968]
        
        AlkB Homolog 8, tRNA Methyltransferase [D08.811.682.690.416.139.984]
        
        Alpha-Ketoglutarate-Dependent Dioxygenase FTO [D08.811.682.690.416.139.992]
        
        Catechol 1,2-Dioxygenase [D08.811.682.690.416.277]
        
        Catechol 2,3-Dioxygenase [D08.811.682.690.416.305]
        
        Cysteine Dioxygenase [D08.811.682.690.416.319]
        
        Homogentisate 1,2-Dioxygenase [D08.811.682.690.416.326]
        
        3-Hydroxyanthranilate 3,4-Dioxygenase [D08.811.682.690.416.328]
        
        4-Hydroxyphenylpyruvate Dioxygenase [D08.811.682.690.416.330]
        
        Indoleamine-Pyrrole 2,3,-Dioxygenase [D08.811.682.690.416.333]
        
        Jumonji Domain-Containing Histone Demethylases [D08.811.682.690.416.388]
        
        Lipoxygenases [D08.811.682.690.416.583]
        
        Prolyl Hydroxylases [D08.811.682.690.416.617]
        
        Protocatechuate-3,4-Dioxygenase [D08.811.682.690.416.652]
        
        Tryptophan Oxygenase [D08.811.682.690.416.722]

AlkB Enzymes Preferred

Concept UI: M000614938
Registry Number: EC 1.14.11.33
Scope Note: A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE).
Terms: AlkB Enzymes Preferred Term
Term UI T000898921
Date04/14/2016
LexicalTag ABX
ThesaurusID NLM (2017); Alkylated DNA Repair Protein AlkB Homologs
Term UI T000895781
Date02/23/2016
LexicalTag ABX
ThesaurusID NLM (2017); Alkylation Repair Homolog Proteins
Term UI T000897306
Date03/18/2016
LexicalTag NON
ThesaurusID NLM (2017); Alkylation Repair Homologs
Term UI T000895712
Date02/22/2016
LexicalTag NON
ThesaurusID NLM (2017); AlkB Homologs
Term UI T000895782
Date02/23/2016
LexicalTag ABX
ThesaurusID NLM (2017)

AlkB Enzymes MeSH Descriptor Data 2023