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MutL Proteins MeSH Descriptor Data 2022


MeSH Heading
MutL Proteins
Tree Number(s)
D08.811.074.766
D08.811.277.040.025.215
D12.776.260.540
Unique ID
D000070956
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000070956
Scope Note
DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.
Entry Term(s)
MutL Homologs
Registry Number
EC 3.6.1.3
Previous Indexing
Adenosine Triphosphatases (1992-2016)
DNA Repair (1982-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/02/26
MutL Proteins Preferred
MutL Homologs Narrower
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