MeSH Browser

MeSH Heading: Interferon-Stimulated Gene Factor 3
Tree Number(s): D12.644.360.024.303; D12.776.157.057.061; D12.776.260.513; D12.776.476.024.386; D12.776.930.354
Unique ID: D050832
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050832
Scope Note: A multimeric complex that functions as a ligand-dependent transcription factor. ISGF3 is assembled in the CYTOPLASM and translocated to the CELL NUCLEUS in response to INTERFERON signaling. It consists of ISGF3-GAMMA and ISGF3-ALPHA, and it regulates expression of many interferon-responsive GENES.
Entry Term(s): IFN-Stimulated Gene Factor 3 Complex; ISGF3 Factor; ISGF3 Transcription Factor; Transcription Factor ISGF3
Public MeSH Note: 2006; INTERFERON-STIMULATED GENE FACTOR 3 was indexed under DNA-BINDING PROTEINS & TRANSCRIPTION FACTORS 1990-2005
History Note: 2006(1990)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2015/11/23

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0181861
Scope Note: A multimeric complex that functions as a ligand-dependent transcription factor. ISGF3 is assembled in the CYTOPLASM and translocated to the CELL NUCLEUS in response to INTERFERON signaling. It consists of ISGF3-GAMMA and ISGF3-ALPHA, and it regulates expression of many interferon-responsive GENES.
Terms: Interferon-Stimulated Gene Factor 3 Preferred Term
Term UI T211866
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); ISGF3 Factor
Term UI T211859
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2006); Transcription Factor ISGF3
Term UI T211865
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2006); IFN-Stimulated Gene Factor 3 Complex
Term UI T519860
Date09/18/2002
LexicalTag ABX
ThesaurusID NLM (2006); ISGF3 Transcription Factor
Term UI T631242
Date02/22/2005
LexicalTag ABX
ThesaurusID NLM (2006)

Interferon-Stimulated Gene Factor 3 MeSH Descriptor Data 2025