MeSH Browser

MeSH Heading: Kelch-Like ECH-Associated Protein 1
Tree Number(s): D12.644.360.024.306; D12.776.157.057.067; D12.776.476.024.387
Unique ID: D000072019
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000072019
Scope Note: An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS.
Entry Term(s): KEAP-1 Protein; KEAP1 Protein
Registry Number: 0
Previous Indexing: Adaptor Proteins, Signal Transducing (2005-2016); Carrier Proteins (1999-2016); Intracellular Signaling Peptides and Proteins (2004-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000616243
Registry Number: 0
Scope Note: An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS.
Terms: Kelch-Like ECH-Associated Protein 1 Preferred Term
Term UI T000897875
Date03/29/2016
LexicalTag NON
ThesaurusID NLM (2017); KEAP-1 Protein
Term UI T000900384
Date05/04/2016
LexicalTag ACX
ThesaurusID NLM (2017); KEAP1 Protein
Term UI T000900383
Date05/04/2016
LexicalTag ACX
ThesaurusID NLM (2017)

Kelch-Like ECH-Associated Protein 1 MeSH Descriptor Data 2023