Regulatory-Associated Protein of mTOR MeSH Descriptor Data 2025

MeSH Heading: Regulatory-Associated Protein of mTOR
Tree Number(s): D05.500.337.500; D08.811.913.696.620.682.700.931.500.500; D12.644.360.024.324; D12.776.157.057.157; D12.776.476.024.419; D12.776.476.563.931.500.500
Unique ID: D000076223
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000076223
Scope Note: An adaptor protein component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 that forms stoichiometric complexes with TOR KINASES, which it negatively regulates. It functions as a positive regulator of RIBOSOMAL PROTEIN S6 KINASES.
Entry Term(s): RAPTOR Protein; RPTOR Protein
Previous Indexing: Adaptor Proteins, Signal Transducing (2011-2017); Proteins (2002-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Macromolecular Substances [D05]
- Multiprotein Complexes [D05.500]
  - Mechanistic Target of Rapamycin Complex 1 [D05.500.337]
    - mTOR Associated Protein, LST8 Homolog [D05.500.337.250]
    - Regulatory-Associated Protein of mTOR [D05.500.337.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931]
        
        Mechanistic Target of Rapamycin Complex 1 [D08.811.913.696.620.682.700.931.500]
        
        mTOR Associated Protein, LST8 Homolog [D08.811.913.696.620.682.700.931.500.250]
        
        Regulatory-Associated Protein of mTOR [D08.811.913.696.620.682.700.931.500.500]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Adaptor Proteins, Signal Transducing [D12.644.360.024]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Adaptor Proteins, Signal Transducing [D12.776.157.057]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Adaptor Proteins, Signal Transducing [D12.776.476.024]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - TOR Serine-Threonine Kinases [D12.776.476.563.931]
        
        Mechanistic Target of Rapamycin Complex 1 [D12.776.476.563.931.500]
        
        mTOR Associated Protein, LST8 Homolog [D12.776.476.563.931.500.250]
        
        Regulatory-Associated Protein of mTOR [D12.776.476.563.931.500.500]

Regulatory-Associated Protein of mTOR Preferred

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