MeSH Browser

MeSH Heading: Sequestosome-1 Protein
Tree Number(s): D12.644.360.024.329; D12.776.094.750; D12.776.157.057.160; D12.776.476.024.422
Unique ID: D000071456
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071456
Scope Note: A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.
Entry Term(s): EBI3-Associated Protein of 60 KDa; EBIAP Protein; Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda; Ubiquitin-Binding Protein p62
Registry Numbers: 0
Previous Indexing: Adaptor Proteins, Signal Transducing (1996-2016); Heat-Shock Proteins (1996-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/04/15

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000614776
Registry Numbers: 0
Scope Note: A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.
Terms: Sequestosome-1 Protein Preferred Term
Term UI T000895532
Date02/18/2016
LexicalTag NON
ThesaurusID NLM (2017); EBI3-Associated Protein of 60 KDa
Term UI T000895534
Date02/18/2016
LexicalTag ABX
ThesaurusID NLM (2017); EBIAP Protein
Term UI T000895535
Date02/18/2016
LexicalTag ABX
ThesaurusID NLM (2017); Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda
Term UI T000895538
Date02/18/2016
LexicalTag ABX
ThesaurusID NLM (2017); Ubiquitin-Binding Protein p62
Term UI T000895539
Date02/18/2016
LexicalTag ABX
ThesaurusID NLM (2017)

Sequestosome-1 Protein MeSH Descriptor Data 2025