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Mediator Complex MeSH Descriptor Data 2023


MeSH Heading
Mediator Complex
Tree Number(s)
D05.500.374
D12.644.360.024.309
D12.776.157.057.072
D12.776.476.024.388
D12.776.660.551
Unique ID
D056892
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D056892
Scope Note
A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.
Entry Term(s)
Mediator Transcription Complex
Mediator-Like Complex
Mediator-Like Complexes
TR-Associated Protein (TRAP) Complex
TRAP (Thyroid Hormone Associated Protein) Complex
Thyroid Hormone-Associated Protein Complex
Registry Number
0
Previous Indexing
RNA Polymerase II (1994-2009)
Transcription Factors (1994-2009)
Public MeSH Note
2010; TRAP (THYROID HORMONE ASSOCIATED PROTEIN) COMPLEX, TR-ASSOCIATED PROTEIN (TRAP) COMPLEX and THYROID HORMONE-ASSOCIATED PROTEIN COMPLEX were indexed under TRANSCRIPTION FACTORS 2003-2009
History Note
2010; for TRAP (THYROID HORMONE ASSOCIATED PROTEIN) COMPLEX, TR-ASSOCIATED PROTEIN (TRAP) COMPLEX and THYROID HORMONE-ASSOCIATED PROTEIN COMPLEX use MEDIATOR COMPLEX SUBUNIT 1 2003-2009
Date Established
2010/01/01
Date of Entry
2009/07/06
Revision Date
2016/03/30
Mediator Complex Preferred
Thyroid Hormone-Associated Protein Complex Narrower
Mediator-Like Complexes Narrower
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