MeSH Browser

MeSH Heading: Retinoblastoma-Like Protein p130
Tree Number(s): D12.776.624.776.735; D12.776.660.794; D12.776.744.755
Unique ID: D050717
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050717
Scope Note: A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. RBL2 contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and E2F5 TRANSCRIPTION FACTOR. RBL2 also interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.
Entry Term(s): RBL2 Protein; Retinoblastoma Like Protein p130; Retinoblastoma-Like Protein 2
Public MeSH Note: 2006; RETINOBLASTOMA-LIKE PROTEIN P130 was indexed under PROTEIN 2004-2005, under ADAPTOR PROTEINS 2004, under PHOSPHOPROTEINS 1996-2004, & under PROTEINS 1994-1995
History Note: 2006(1994)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 1955/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Retinoblastoma-Like Protein p130 MeSH Descriptor Data 2025