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PTEN Phosphohydrolase MeSH Descriptor Data 2021


MeSH Heading
PTEN Phosphohydrolase
Tree Number(s)
D08.811.277.352.650.850
D12.776.476.590
D12.776.624.776.695
Unique ID
D051059
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D051059
Scope Note
A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.
Entry Term(s)
MMAC1 Protein
Mutated In Multiple Advanced Cancers 1 Protein
PTEN Phosphatase
PTEN Protein
PTEN Protein Phosphatase
Phosphatase and Tensin Homologue on Chromosome Ten Protein
Registry Number
EC 3.1.3.67
Public MeSH Note
2006; PTEN PROTEIN was indexed under PROTEIN-TYROSINE-PHOSPHATASES 1997-1998, under TUMOR SUPPRESSOR PROTEINS 1997-2005, & under PHOSPHORIC MONOESTER HYDROLASES 1999-2005
History Note
2006(1997)
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2015/11/23
PTEN Phosphohydrolase Preferred
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