MeSH Browser

MeSH Heading: PTEN Phosphohydrolase
Tree Number(s): D08.811.277.352.650.850; D12.776.476.590; D12.776.624.776.695
Unique ID: D051059
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051059
Scope Note: A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.
Entry Term(s): MMAC1 Protein; Mutated In Multiple Advanced Cancers 1 Protein; PTEN Phosphatase; PTEN Protein; PTEN Protein Phosphatase; Phosphatase and Tensin Homologue on Chromosome Ten Protein
Public MeSH Note: 2006; PTEN PROTEIN was indexed under PROTEIN-TYROSINE-PHOSPHATASES 1997-1998, under TUMOR SUPPRESSOR PROTEINS 1997-2005, & under PHOSPHORIC MONOESTER HYDROLASES 1999-2005
History Note: 2006(1997)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2015/11/23

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

PTEN Phosphohydrolase MeSH Descriptor Data 2025