MeSH Browser

MeSH Heading: I-kappa B Proteins
Tree Number(s): D12.644.360.365; D12.776.260.420; D12.776.476.381; D12.776.930.326
Unique ID: D020672
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020672
Scope Note: A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.
Entry Term(s): I kappa B; I-kappa B; IkB DNA-Binding Proteins
Previous Indexing: DNA-Binding Proteins (1998-1999); Proto-Oncogene Proteins (1993-1998)
See Also: I-kappa B Kinase; NF-kappa B; Proto-Oncogene Proteins c-rel
Public MeSH Note: 2000; see I KAPPA B 2000-2005, I KAPPA B PROTEINS was indexed under PROTO-ONCOGENE PROTEINS 1993-1998 & DNA-BINDING PROTEINS 1998-1999
History Note: 2006(2000)
Date Established: 2000/01/01
Date of Entry: 1999/11/04
Revision Date: 2017/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0328543
Scope Note: A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.
Terms: I-kappa B Proteins Preferred Term
Term UI T637943
Date04/26/2005
LexicalTag NON
ThesaurusID NLM (2006); I-kappa B
Term UI T327212
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); I kappa B
Term UI T327213
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); IkB DNA-Binding Proteins
Term UI T637944
Date04/26/2005
LexicalTag ABX
ThesaurusID NLM (2006)

I-kappa B Proteins MeSH Descriptor Data 2025