- Concept UI
- M0029257
- Scope Note
- A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
- Terms
-
Calcineurin
Preferred Term
Term UI
T058604
Date01/01/1999
LexicalTag
NON
ThesaurusID
NLM (1998)
-
Protein Phosphatase-2B
Term UI
T058603
Date01/30/1997
LexicalTag
NON
ThesaurusID
NLM (1998)
-
Protein Phosphatase 3
Term UI
T712674
Date01/11/2008
LexicalTag
NON
ThesaurusID
NLM (2009)