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Tuberous Sclerosis Complex 2 Protein MeSH Descriptor Data 2023


MeSH Heading
Tuberous Sclerosis Complex 2 Protein
Tree Number(s)
D12.644.360.938
D12.776.476.935
D12.776.624.776.769
Unique ID
D000077005
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077005
Scope Note
An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN (TSC1) and other signaling factors to negatively regulate MTORC1 and affect cell growth and proliferation. It can also function as GTPASE-ACTIVATING PROTEIN (GAP) for RHEB GTPASE to activate mTORC1 independent of its role in the complex. Structurally, it interacts with TSC1 through its N-terminus, which also contains a leucine zipper and coiled-coil region. It also has multiple phosphorylation sites for different cell signaling kinases, a central coiled-coil region, a C-terminal GAP domain and CALMODULIN binding domain. Mutations in the TSC2 gene are associated with TUBEROUS SCLEROSIS.
Entry Term(s)
Tuberin
Tuberous Sclerosis 2 Protein
Registry Number
0
Public MeSH Note
2019; TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN was indexed under TUMOR SUPPRESSOR PROTEINS 2006-2018 and under REPRESSOR PROTEINS 1994-2005
History Note
2019 (1994)
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2018/06/19
Tuberous Sclerosis Complex 2 Protein Preferred
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