Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Tuberous Sclerosis Complex 2 Protein MeSH Descriptor Data 2026


MeSH Heading
Tuberous Sclerosis Complex 2 Protein
Tree Number(s)
D12.644.360.938
D12.776.476.935
D12.776.624.776.769
Unique ID
D000077005
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077005
Scope Note
An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN (TSC1) and other signaling factors to negatively regulate MTORC1 and affect cell growth and proliferation. It can also function as GTPASE-ACTIVATING PROTEIN (GAP) for RHEB GTPASE to activate mTORC1 independent of its role in the complex. Structurally, it interacts with TSC1 through its N-terminus, which also contains a leucine zipper and coiled-coil region. It also has multiple phosphorylation sites for different cell signaling kinases, a central coiled-coil region, a C-terminal GAP domain and CALMODULIN binding domain. Mutations in the TSC2 gene are associated with TUBEROUS SCLEROSIS.
Entry Term(s)
Tuberin
Tuberous Sclerosis 2 Protein
Registry Numbers
0
Public MeSH Note
2019; TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN was indexed under TUMOR SUPPRESSOR PROTEINS 2006-2018 and under REPRESSOR PROTEINS 1994-2005
History Note
2019 (1994)
Date Introduced
2019/01/01
Last Updated
2019/01/01
Tuberous Sclerosis Complex 2 Protein Preferred
page delivered in 0.191s