MeSH Browser

MeSH Heading: Tuberous Sclerosis Complex 2 Protein
Tree Number(s): D12.644.360.938; D12.776.476.935; D12.776.624.776.769
Unique ID: D000077005
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077005
Scope Note: An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN (TSC1) and other signaling factors to negatively regulate MTORC1 and affect cell growth and proliferation. It can also function as GTPASE-ACTIVATING PROTEIN (GAP) for RHEB GTPASE to activate mTORC1 independent of its role in the complex. Structurally, it interacts with TSC1 through its N-terminus, which also contains a leucine zipper and coiled-coil region. It also has multiple phosphorylation sites for different cell signaling kinases, a central coiled-coil region, a C-terminal GAP domain and CALMODULIN binding domain. Mutations in the TSC2 gene are associated with TUBEROUS SCLEROSIS.
Entry Term(s): Tuberin; Tuberous Sclerosis 2 Protein
Registry Number: 0
Public MeSH Note: 2019; TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN was indexed under TUMOR SUPPRESSOR PROTEINS 2006-2018 and under REPRESSOR PROTEINS 1994-2005
History Note: 2019 (1994)
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/06/19

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0239300
Registry Number: 0
Scope Note: An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN (TSC1) and other signaling factors to negatively regulate MTORC1 and affect cell growth and proliferation. It can also function as GTPASE-ACTIVATING PROTEIN (GAP) for RHEB GTPASE to activate mTORC1 independent of its role in the complex. Structurally, it interacts with TSC1 through its N-terminus, which also contains a leucine zipper and coiled-coil region. It also has multiple phosphorylation sites for different cell signaling kinases, a central coiled-coil region, a C-terminal GAP domain and CALMODULIN binding domain. Mutations in the TSC2 gene are associated with TUBEROUS SCLEROSIS.
Terms: Tuberous Sclerosis Complex 2 Protein Preferred Term
Term UI T000936106
Date11/17/2017
LexicalTag NON
ThesaurusID NLM (2006); Tuberous Sclerosis 2 Protein
Term UI T000936108
Date11/17/2017
LexicalTag NON
ThesaurusID NLM (1994); Tuberin
Term UI T000936107
Date11/17/2017
LexicalTag NON
ThesaurusID NLM (1994)

Tuberous Sclerosis Complex 2 Protein MeSH Descriptor Data 2023