MeSH Browser

MeSH Heading: Neurofibromin 1
Tree Number(s): D12.644.360.325.150.500.460; D12.776.476.325.150.500.460; D12.776.624.776.610
Unique ID: D025542
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D025542
Scope Note: A protein found most abundantly in the nervous system. Defects or deficiencies in this protein are associated with NEUROFIBROMATOSIS 1, Watson syndrome, and LEOPARD syndrome. Mutations in the gene (GENE, NEUROFIBROMATOSIS 1) affect two known functions: regulation of ras-GTPase and tumor suppression.
Entry Term(s): NF-1 Protein; NF1 GRP; NF1 Protein; NF1-GAP-Related Protein; Neurofibromatosis Type 1 Gene Product; Neurofibromatosis Type 1 Protein; Neurofibromin
Previous Indexing: Nerve Tissue Proteins (1995-2001); Proteins (1990-1999)
See Also: Genes, Neurofibromatosis 1; Neurofibromatosis 1
Public MeSH Note: 2002
History Note: 2002
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2015/11/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0179586
Scope Note: A protein found most abundantly in the nervous system. Defects or deficiencies in this protein are associated with NEUROFIBROMATOSIS 1, Watson syndrome, and LEOPARD syndrome. Mutations in the gene (GENE, NEUROFIBROMATOSIS 1) affect two known functions: regulation of ras-GTPase and tumor suppression.
Terms: Neurofibromin 1 Preferred Term
Term UI T431481
Date12/20/2000
LexicalTag NON
ThesaurusID NLM (2002); NF-1 Protein
Term UI T209585
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2002); NF1 GRP
Term UI T209586
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2002); NF1 Protein
Term UI T209587
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2002); Neurofibromatosis Type 1 Gene Product
Term UI T209589
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Neurofibromin
Term UI T209590
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Neurofibromatosis Type 1 Protein
Term UI T209591
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); NF1-GAP-Related Protein
Term UI T209588
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2002)

Neurofibromin 1 MeSH Descriptor Data 2025