MeSH Browser

MeSH Heading: Fanconi Anemia Complementation Group N Protein
Tree Number(s): D12.776.313.953; D12.776.624.776.051; D12.776.660.323
Unique ID: D000076164
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000076164
Scope Note: A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.
Entry Term(s): FANCN Protein; PALB2 Protein; Partner and Localizer of BRCA2 Protein
Previous Indexing: Nuclear Proteins (2006-2017); Tumor Suppressor Proteins (2006-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000632389
Scope Note: A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.
Terms: Fanconi Anemia Complementation Group N Protein Preferred Term
Term UI T000925674
Date05/30/2017
LexicalTag NON
ThesaurusID NLM (2018); Partner and Localizer of BRCA2 Protein
Term UI T000925676
Date05/30/2017
LexicalTag ABX
ThesaurusID NLM (2018); FANCN Protein
Term UI T000925675
Date05/30/2017
LexicalTag ABX
ThesaurusID NLM (2018); PALB2 Protein
Term UI T000925677
Date05/30/2017
LexicalTag ABX
ThesaurusID NLM (2018)

Fanconi Anemia Complementation Group N Protein MeSH Descriptor Data 2025