MeSH Browser

MeSH Heading: Tumor Suppressor Protein p14ARF
Tree Number(s): D12.776.167.600; D12.776.624.776.772
Unique ID: D025803
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D025803
Scope Note: A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of MDM2 PROTEIN (which regulates P53 TUMOR SUPPRESSOR PROTEIN by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is CYCLIN-DEPENDENT KINASE INHIBITOR P16. Both p16 gene products have tumor suppressor functions.
Entry Term(s): Cdkn2a(p14ARF); p(ARF) Protein; p14(ARF); p14ARF; p14ARF Protein
Registry Number: 0
See Also: Cyclin-Dependent Kinase Inhibitor p16; Genes, p16
Public MeSH Note: 2002; TUMOR SUPPRESSOR PROTEIN P14ARF was indexed under P14ARF PROTEIN 2002-2005, & under PROTEINS 1996-2001
History Note: 2002(1996)
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0255541
Registry Number: 0
Scope Note: A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of MDM2 PROTEIN (which regulates P53 TUMOR SUPPRESSOR PROTEIN by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is CYCLIN-DEPENDENT KINASE INHIBITOR P16. Both p16 gene products have tumor suppressor functions.
Terms: Tumor Suppressor Protein p14ARF Preferred Term
Term UI T632643
Date03/08/2005
LexicalTag ACX
ThesaurusID NLM (2006); p14ARF Protein
Term UI T432577
Date01/08/2001
LexicalTag ACX
ThesaurusID NLM (2002); p14(ARF)
Term UI T285541
LexicalTag NON
ThesaurusID NLM (2002); p14ARF
Term UI T285542
LexicalTag ACX
ThesaurusID NLM (2002); Cdkn2a(p14ARF)
Term UI T430439
Date12/06/2000
LexicalTag ACX
ThesaurusID NLM (2002); p(ARF) Protein
Term UI T435873
Date02/12/2001
LexicalTag NON
ThesaurusID NLM (2002)

Tumor Suppressor Protein p14ARF MeSH Descriptor Data 2023