MeSH Browser

MeSH Heading: Valosin Containing Protein
Tree Number(s): D08.811.277.040.013.500.750; D08.811.277.040.025.024.750; D12.776.157.025.750.750; D12.776.167.800
Unique ID: D000074405
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074405
Scope Note: A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.
Entry Term(s): CDC48 Protein; Cell Cycle Protein CDC48; Cell Cycle Protein CDC48p; Valosin-Containing Protein; Valosine-Containing Protein; p97 Valosin-Containing Protein
Registry Number: EC 3.6.4.6
Public MeSH Note: 2018; VALOSIN CONTAINING PROTEIN was indexed under ADENOSINE TRIPHOSPHATASES and CELL CYCLE PROTEINS 1991-2017
History Note: 2018 (1991)
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/02

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Acid Anhydride Hydrolases [D08.811.277.040]
      - AAA Proteins [D08.811.277.040.013]
        
        ATPases Associated with Diverse Cellular Activities [D08.811.277.040.013.500]
        
        ATP-Dependent Proteases [D08.811.277.040.013.500.032]
        
        Dyneins [D08.811.277.040.013.500.063]
        
        Katanin [D08.811.277.040.013.500.250]
        
        N-Ethylmaleimide-Sensitive Proteins [D08.811.277.040.013.500.375]
        
        Replication Protein C [D08.811.277.040.013.500.438]
        
        Spastin [D08.811.277.040.013.500.500]
        
        Valosin Containing Protein [D08.811.277.040.013.500.750]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Acid Anhydride Hydrolases [D08.811.277.040]
      - Adenosine Triphosphatases [D08.811.277.040.025]
        
        ATPases Associated with Diverse Cellular Activities [D08.811.277.040.025.024]
        
        ATP-Dependent Proteases [D08.811.277.040.025.024.032]
        
        Dyneins [D08.811.277.040.025.024.063]
        
        Katanin [D08.811.277.040.025.024.250]
        
        N-Ethylmaleimide-Sensitive Proteins [D08.811.277.040.025.024.375]
        
        Replication Protein C [D08.811.277.040.025.024.438]
        
        Spastin [D08.811.277.040.025.024.500]
        
        Valosin Containing Protein [D08.811.277.040.025.024.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - AAA Proteins [D12.776.157.025]
      - ATPases Associated with Diverse Cellular Activities [D12.776.157.025.750]
        
        ATP-Dependent Proteases [D12.776.157.025.750.032]
        
        Dyneins [D12.776.157.025.750.063]
        
        Katanin [D12.776.157.025.750.250]
        
        N-Ethylmaleimide-Sensitive Proteins [D12.776.157.025.750.375]
        
        Replication Protein C [D12.776.157.025.750.438]
        
        Spastin [D12.776.157.025.750.500]
        
        Valosin Containing Protein [D12.776.157.025.750.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Cell Cycle Proteins [D12.776.167]

Valosin Containing Protein Preferred

Concept UI: M000626473
Registry Number: EC 3.6.4.6
Scope Note: A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.
Terms: Valosin Containing Protein Preferred Term
Term UI T000915746
Date02/13/2017
LexicalTag NON
ThesaurusID NLM (2018); Cell Cycle Protein CDC48
Term UI T000915750
Date02/13/2017
LexicalTag ABX
ThesaurusID NLM (2005); Valosine-Containing Protein
Term UI T000915754
Date02/13/2017
LexicalTag NON
ThesaurusID NLM (1991); p97 Valosin-Containing Protein
Term UI T000915752
Date02/13/2017
LexicalTag ABX
ThesaurusID NLM (2005); Valosin-Containing Protein
Term UI T000915753
Date02/13/2017
LexicalTag NON
ThesaurusID NLM (1991); CDC48 Protein
Term UI T000915749
Date02/13/2017
LexicalTag ABX
ThesaurusID NLM (1991); Cell Cycle Protein CDC48p
Term UI T000915751
Date02/13/2017
LexicalTag ABX
ThesaurusID NLM (1991)

Valosin Containing Protein MeSH Descriptor Data 2023