MeSH Browser

MeSH Heading: Proteasome Endopeptidase Complex
Tree Number(s): D05.500.562.500; D08.811.277.656.918; D08.811.600.730
Unique ID: D046988
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D046988
Scope Note: A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Entry Term(s): 20S Proteasome; Ingensin; Macropain; Macroxyproteinase; Multicatalytic Endopeptidase Complex; Multicatalytic Proteinase; Prosome; Proteasome
Related Numbers: EC 3.4.25.1
Previous Indexing: Cysteine Endopeptidases (1986-2004); Multienzyme Complexes (1986-2004)
See Also: Ubiquitin-Protein Ligase Complexes
Public MeSH Note: 2005; PROTEASOME ENDOPEPTIDASE COMPLEX was indexed under CYSTEINE ENDOPEPTIDASES & MULTIENZYME COMPLEXES 1986-2004
History Note: 2005; use PROTEASOME ENDOPEPTIDASE COMPLEX (NM) 1986-2004
Entry Combination: antagonists & inhibitors:Proteasome Inhibitors
Date Established: 2005/01/01
Date of Entry: 2004/07/07
Revision Date: 2012/07/03

Entry Combination: antagonists & inhibitors:Proteasome Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0140424
Related Numbers: EC 3.4.25.1
Scope Note: A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Terms: Proteasome Endopeptidase Complex Preferred Term
Term UI T558332
Date11/14/2003
LexicalTag NON
ThesaurusID NLM (2005); Macroxyproteinase
Term UI T170424
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); Multicatalytic Endopeptidase Complex
Term UI T170429
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); Multicatalytic Proteinase
Term UI T170426
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); Prosome
Term UI T170427
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); Proteasome
Term UI T170428
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); Macropain
Term UI T170423
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); 20S Proteasome
Term UI T170420
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005)

Proteasome Endopeptidase Complex MeSH Descriptor Data 2025