MeSH Browser

MeSH Heading: Metalloproteases
Tree Number(s): D08.811.277.656.675
Unique ID: D045726
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D045726
Annotation: general or unspecified; prefer specifics
Scope Note: Proteases which use a metal, normally ZINC, in the catalytic mechanism. This group of enzymes is inactivated by metal CHELATORS.
Entry Term(s): Metallopeptidase; Metallopeptidases; Metalloprotease; Metalloproteinase; Metalloproteinases
Previous Indexing: Metalloendopeptidases (1987-2003)
Public MeSH Note: 2004; see METALLOENDOPEPTIDASES 1988-2003
History Note: 2004; use METALLOENDOPEPTIDASES 1988-2003
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0449114
Scope Note: Proteases which use a metal, normally ZINC, in the catalytic mechanism. This group of enzymes is inactivated by metal CHELATORS.
Terms: Metalloproteases Preferred Term
Term UI T025772
Date05/04/1987
LexicalTag NON
ThesaurusID UNK (19XX); Metallopeptidase
Term UI T001007242
Date02/10/2020
LexicalTag NON
ThesaurusID NLM (2021); Metalloprotease
Term UI T000996317
Date11/14/2019
LexicalTag NON
ThesaurusID NLM (2021); Metalloproteinase
Term UI T000996289
Date11/14/2019
LexicalTag NON
ThesaurusID NLM (2021); Metallopeptidases
Term UI T540795
Date05/14/2003
LexicalTag NON
ThesaurusID NLM (2004); Metalloproteinases
Term UI T025773
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1988)

Metalloproteases MeSH Descriptor Data 2025