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Ubiquitin-Protein Ligase Complexes MeSH Descriptor Data 2022


MeSH Heading
Ubiquitin-Protein Ligase Complexes
Tree Number(s)
D08.811.464.938
Unique ID
D043743
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D043743
Annotation
UBIQUITIN-PROTEIN LIGASES is also available
Scope Note
Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).
Registry Number
EC 2.3.2.23
Related Numbers
EC 2.3.2.26
EC 2.3.2.27
EC 6.2.1.45
Previous Indexing
Ligases (1983-2003)
Public MeSH Note
2004
History Note
2004
Date Established
2004/01/01
Date of Entry
2003/07/09
Revision Date
2016/06/02
Ubiquitin-Protein Ligase Complexes Preferred
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