MeSH Browser

MeSH Heading: Electron Transport Complex IV
Tree Number(s): D05.500.562.374; D08.811.600.250.687; D08.811.682.285; D12.776.157.530.450.250.875.304; D12.776.543.277.687; D12.776.543.585.450.250.875.484
Unique ID: D003576
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003576
Annotation: spell in titles & translations with lowercase c: cytochrome-c oxidase
Scope Note: A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.
Entry Term(s): Cytochrome Oxidase; Cytochrome Oxidase Subunit III; Cytochrome a,a3; Cytochrome aa3; Cytochrome c Oxidase Subunit VIa; Cytochrome-c Oxidase; Cytochrome-c Oxidase (Complex IV); Cytochrome-c Oxidase Subunit III; Cytochrome-c Oxidase Subunit IV; Ferrocytochrome c Oxygen Oxidoreductase; Heme aa3 Cytochrome Oxidase; Pre-CTOX p25; Signal Peptide p25-Subunit IV Cytochrome Oxidase; Subunit III, Cytochrome Oxidase; p25 Presequence Peptide-Cytochrome Oxidase
Related Numbers: EC 1.9.3.1
CAS Type 1 Name: Ferricytochrome-c:oxygen oxidoreductase
NLM Classification #: QU 140
See Also: Cytochrome-c Oxidase Deficiency
Public MeSH Note: 2004; see CYTOCHROME-C OXIDASE 1994-2003, see CYTOCHROME C OXIDASE 1992-1993, see CYTOCHROME OXIDASE 1963-1991; for CYTOCHROME C OXIDASE see CYTOCHROME OXIDASE 1984-1991; SIGNAL PEPTIDE P25-SUBUNIT IV CYTOCHROME OXIDASE was indexed under CYTOCHROME C OXIDASE 1988-2001; CYTOCHROME OXIDASE SUBUNIT III was indexed under CYTOCHROME C OXIDASE 1998-2001
History Note: 2004(1963); for SIGNAL PEPTIDE P25-SUBUNIT IV CYTOCHROME OXIDASE use CYTOCHROME C OXIDASE (NM) 1988-2001; for CYTOCHROME OXIDASE SUBUNIT III use CYTOCHROME C OXIDASE (NM) 1998-2001
Entry Combination: deficiency:Cytochrome-c Oxidase Deficiency
Date Established: 2004/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/09

Entry Combination: deficiency:Cytochrome-c Oxidase Deficiency
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Macromolecular Substances [D05]
- Multiprotein Complexes [D05.500]
  - Multienzyme Complexes [D05.500.562]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Multienzyme Complexes [D08.811.600]
    - Electron Transport Chain Complex Proteins [D08.811.600.250]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        Cation Transport Proteins [D12.776.157.530.450.250]
        
        Proton Pumps [D12.776.157.530.450.250.875]
        
        Bacteriorhodopsins [D12.776.157.530.450.250.875.249]
        
        Electron Transport Complex I [D12.776.157.530.450.250.875.300]
        
        Electron Transport Complex III [D12.776.157.530.450.250.875.303]
        
        Electron Transport Complex IV [D12.776.157.530.450.250.875.304]
        
        Inorganic Pyrophosphatase [D12.776.157.530.450.250.875.487]
        
        Photosystem I Protein Complex [D12.776.157.530.450.250.875.492]
        
        Proton-Translocating ATPases [D12.776.157.530.450.250.875.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Electron Transport Chain Complex Proteins [D12.776.543.277]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        Cation Transport Proteins [D12.776.543.585.450.250]
        
        Proton Pumps [D12.776.543.585.450.250.875]
        
        Bacteriorhodopsins [D12.776.543.585.450.250.875.249]
        
        Cytochrome b6f Complex [D12.776.543.585.450.250.875.311]
        
        Electron Transport Complex I [D12.776.543.585.450.250.875.437]
        
        Electron Transport Complex III [D12.776.543.585.450.250.875.468]
        
        Electron Transport Complex IV [D12.776.543.585.450.250.875.484]
        
        Inorganic Pyrophosphatase [D12.776.543.585.450.250.875.487]
        
        Photosystem I Protein Complex [D12.776.543.585.450.250.875.492]
        
        Proton-Translocating ATPases [D12.776.543.585.450.250.875.500]

Electron Transport Complex IV Preferred

Concept UI: M0005587
Related Numbers: EC 1.9.3.1
Scope Note: A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.
Terms: Electron Transport Complex IV Preferred Term
Term UI T536794
Date03/28/2003
LexicalTag NON
ThesaurusID NLM (2004); Cytochrome Oxidase
Term UI T010397
Date03/13/1991
LexicalTag NON
ThesaurusID NLM (1992); Cytochrome-c Oxidase
Term UI T010395
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); Cytochrome-c Oxidase (Complex IV)
Term UI T010405
Date02/08/1989
LexicalTag NON
ThesaurusID NLM (1989); Ferrocytochrome c Oxygen Oxidoreductase
Term UI T010399
Date07/28/1981
LexicalTag NON
ThesaurusID UNK (19XX)

Signal Peptide p25-Subunit IV Cytochrome Oxidase Narrower

Cytochrome-c Oxidase Subunit III Narrower

Cytochrome-c Oxidase Subunit IV Narrower

Cytochrome c Oxidase Subunit VIa Narrower

Cytochrome aa3 Narrower

Electron Transport Complex IV MeSH Descriptor Data 2025