Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Pyruvate Dehydrogenase Complex MeSH Descriptor Data 2026


MeSH Heading
Pyruvate Dehydrogenase Complex
Tree Number(s)
D05.500.562.625
D08.811.600.741
Unique ID
D011768
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D011768
Scope Note
A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Registry Numbers
0
Previous Indexing
Oxidoreductases (1966-1972)
Pyruvate Oxidase (1966-1972)
Pyruvates (1966-1972)
Public MeSH Note
74
History Note
74(73)
Entry Combination
deficiency:Pyruvate Dehydrogenase Complex Deficiency Disease
Date Introduced
1974/01/01
Last Updated
2008/07/08
Pyruvate Dehydrogenase Complex Preferred
page delivered in 0.146s