MeSH Browser

MeSH Heading: Securin
Tree Number(s): D12.776.167.504
Unique ID: D064249
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D064249
Scope Note: Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.
Entry Term(s): PTTG Protein; Pituitary Tumor-Transforming Gene Protein; Pituitary Tumor-Transforming Proteins
Previous Indexing: Neoplasm Proteins (1997-2013)
Public MeSH Note: 2014; was indexed under NEOPLASM PROTEINS 1997-2013
History Note: 2014
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 1955/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0580548
Scope Note: Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.
Terms: Securin Preferred Term
Term UI T836783
Date02/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Pituitary Tumor-Transforming Gene Protein
Term UI T837065
Date02/07/2013
LexicalTag NON
ThesaurusID NLM (2004); Pituitary Tumor-Transforming Proteins
Term UI T837066
Date02/07/2013
LexicalTag NON
ThesaurusID NLM (2004); PTTG Protein
Term UI T837067
Date02/07/2013
LexicalTag NON
ThesaurusID NLM (1997)

Securin MeSH Descriptor Data 2025