MeSH Browser

MeSH Heading: Cyclin-Dependent Kinase Inhibitor Proteins
Tree Number(s): D12.644.360.225; D12.776.167.187; D12.776.476.225; D12.776.624.776.355
Unique ID: D050756
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050756
Scope Note: A group of cell cycle proteins that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. They inhibit CELL CYCLE progression and help control CELL PROLIFERATION following GENOTOXIC STRESS as well as during CELL DIFFERENTIATION.
Entry Term(s): CDKI Proteins; CIP-KIP CDKI Proteins; CIP-KIP CKI Proteins; CIP-KIP Cyclin-Dependent Kinase Inhibitors; CKI Proteins; Cyclin-Kinase Inhibitor Proteins; INK4 CDKI Proteins; INK4 CKI Proteins; INK4 Cyclin-Dependent Kinase Inhibitors; Inhibitors of Cyclin-Dependent Kinase 4 Proteins
Pharm Action: Protein Kinase Inhibitors
Public MeSH Note: 2006
History Note: 2006
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2015/11/23

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Cyclin-Dependent Kinase Inhibitor Proteins MeSH Descriptor Data 2025