MeSH Browser

MeSH Heading: Cyclin-Dependent Kinase Inhibitor p27
Tree Number(s): D12.644.360.225.600; D12.776.167.187.600; D12.776.476.225.600; D12.776.624.776.355.600
Unique ID: D050760
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050760
Scope Note: A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.
Entry Term(s): CDK Inhibitor p27; CDKN1B Protein; CDKN4 Protein; Cyclin-Dependent Kinase Inhibitor 1B; p27 CDK Inhibitor; p27 Kip1 Protein; p27Kip1 Protein
Pharm Action: Protein Kinase Inhibitors
Public MeSH Note: 2006; CYCLIN-DEPENDENT KINASE INHIBITOR P27 was indexed under CELL CYCLE PROTEINS & TUMOR SUPPRESSOR PROTEINS 1992-2005
History Note: 2006(1992)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2015/11/23

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0203045
Scope Note: A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.
Terms: Cyclin-Dependent Kinase Inhibitor p27 Preferred Term
Term UI T623200
Date12/10/2004
LexicalTag NON
ThesaurusID NLM (2006); CDKN4 Protein
Term UI T233041
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2006); p27 CDK Inhibitor
Term UI T233045
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2006); Cyclin-Dependent Kinase Inhibitor 1B
Term UI T456027
Date08/01/2001
LexicalTag NON
ThesaurusID NLM (2006); CDKN1B Protein
Term UI T623618
Date12/13/2004
LexicalTag ABX
ThesaurusID NLM (2006); p27Kip1 Protein
Term UI T623620
Date12/13/2004
LexicalTag ABX
ThesaurusID NLM (2006); CDK Inhibitor p27
Term UI T233038
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2006); p27 Kip1 Protein
Term UI T623621
Date12/13/2004
LexicalTag ABX
ThesaurusID NLM (2006)

Cyclin-Dependent Kinase Inhibitor p27 MeSH Descriptor Data 2025