Cyclin-Dependent Kinase 2 MeSH Descriptor Data 2025

MeSH Heading: Cyclin-Dependent Kinase 2
Tree Number(s): D08.811.913.696.620.682.700.646.500.750; D12.776.167.200.323; D12.776.476.563.646.500.750
Unique ID: D051357
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051357
Scope Note: A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE and also interacts with CYCLIN A to phosphorylate RETINOBLASTOMA PROTEIN. Its activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P27 and CYCLIN-DEPENDENT KINASE INHIBITOR P21.
Entry Term(s): CDK2 Protein; Cdc2-Related Protein Kinase; Cdk2 Protein Kinase; p33cdk2 Kinase
Public MeSH Note: 2006; CYCLIN-DEPENDENT KINASE 2 was indexed under CDC2-CDC28 KINASES 2004-2005, & under CYCLIN-DEPENDENT KINASES 1991-2003, & under PROTEIN KINASES 1991-1994
History Note: 2006(1991)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
        
        Cyclin-Dependent Kinases [D08.811.913.696.620.682.700.646.500]
        
        CDC2-CDC28 Kinases [D08.811.913.696.620.682.700.646.500.500]
        
        Cyclin-Dependent Kinase 2 [D08.811.913.696.620.682.700.646.500.750]
        
        Cyclin-Dependent Kinase 3 [D08.811.913.696.620.682.700.646.500.812]
        
        Cyclin-Dependent Kinase 4 [D08.811.913.696.620.682.700.646.500.875]
        
        Cyclin-Dependent Kinase 6 [D08.811.913.696.620.682.700.646.500.937]
        
        Cyclin-Dependent Kinase 8 [D08.811.913.696.620.682.700.646.500.968]
        
        Maturation-Promoting Factor [D08.811.913.696.620.682.700.646.500.984]
        
        Cyclin-Dependent Kinase-Activating Kinase [D08.811.913.696.620.682.700.646.500.992]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Cell Cycle Proteins [D12.776.167]
    - Cyclin-Dependent Kinases [D12.776.167.200]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - Proline-Directed Protein Kinases [D12.776.476.563.646]
        
        Cyclin-Dependent Kinases [D12.776.476.563.646.500]
        
        CDC2-CDC28 Kinases [D12.776.476.563.646.500.500]
        
        Cyclin-Dependent Kinase 2 [D12.776.476.563.646.500.750]
        
        Cyclin-Dependent Kinase 3 [D12.776.476.563.646.500.812]
        
        Cyclin-Dependent Kinase 4 [D12.776.476.563.646.500.875]
        
        Cyclin-Dependent Kinase 6 [D12.776.476.563.646.500.937]
        
        Cyclin-Dependent Kinase 8 [D12.776.476.563.646.500.968]
        
        Maturation-Promoting Factor [D12.776.476.563.646.500.984]
        
        Cyclin-Dependent Kinase-Activating Kinase [D12.776.476.563.646.500.992]

Cyclin-Dependent Kinase 2 Preferred

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