MeSH Browser

MeSH Heading: Cyclin-Dependent Kinase 4
Tree Number(s): D08.811.913.696.620.682.700.646.500.875; D12.776.167.200.451; D12.776.476.563.646.500.875
Unique ID: D051358
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051358
Scope Note: Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. It partners with CYCLIN D to phosphorylate RETINOBLASTOMA PROTEIN. CDK4 activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P16.
Entry Term(s): Cdk4 Cyclin-Dependent Kinase; Cdk4 Protein; Cdk4 Protein Kinase; Cell Division Protein Kinase 4; Cyclin D-Dependent Kinase CDK4; PSK-J3 Kinase; p34PSK-J3 Kinase
Public MeSH Note: 2006; CYCLIN-DEPENDENT KINASE 4 was indexed under CYCLIN-DEPENDENT KINASES & PROTO-ONCOGENE PROTEINS 2005, CELL CYCLE PROTEINS 1992-2004, PROTEIN SERINE THREONINE KINASES 1995, & under PROTEIN KINASES 1992-1994
History Note: 2006(1992)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0208277
Scope Note: Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. It partners with CYCLIN D to phosphorylate RETINOBLASTOMA PROTEIN. CDK4 activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P16.
Terms: Cyclin-Dependent Kinase 4 Preferred Term
Term UI T238279
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Cyclin D-Dependent Kinase CDK4
Term UI T238278
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2006); p34PSK-J3 Kinase
Term UI T238282
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2006); Cell Division Protein Kinase 4
Term UI T613733
Date10/17/2004
LexicalTag NON
ThesaurusID NLM (2006); Cdk4 Protein Kinase
Term UI T634007
Date03/22/2005
LexicalTag ABX
ThesaurusID NLM (2006); PSK-J3 Kinase
Term UI T238275
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2006); Cdk4 Protein
Term UI T238277
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2006); Cdk4 Cyclin-Dependent Kinase
Term UI T238276
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2006)

Cyclin-Dependent Kinase 4 MeSH Descriptor Data 2025