Cyclin-Dependent Kinase 8 MeSH Descriptor Data 2025

MeSH Heading: Cyclin-Dependent Kinase 8
Tree Number(s): D05.500.374.500; D08.811.913.696.620.682.700.646.500.968; D12.776.157.057.072.500; D12.776.167.200.548; D12.776.476.024.388.500; D12.776.476.563.646.500.968; D12.776.660.551.500
Unique ID: D056850
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D056850
Scope Note: A CYCLIN C dependent kinase that is an important component of the mediator complex. The enzyme is activated by its interaction with CYCLIN C and plays a role in transcriptional regulation by phosphorylating RNA POLYMERASE II.
Entry Term(s): Cdk8 Cyclin-Dependent Kinase; Cdk8 Protein Kinase; Cell Division Protein Kinase 8
Related Numbers: EC 2.7.11.23
Previous Indexing: Cyclin-Dependent Kinases (1995-2009)
Public MeSH Note: 2010
History Note: 2010
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Macromolecular Substances [D05]
- Multiprotein Complexes [D05.500]
  - Mediator Complex [D05.500.374]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
        
        Cyclin-Dependent Kinases [D08.811.913.696.620.682.700.646.500]
        
        CDC2-CDC28 Kinases [D08.811.913.696.620.682.700.646.500.500]
        
        Cyclin-Dependent Kinase 2 [D08.811.913.696.620.682.700.646.500.750]
        
        Cyclin-Dependent Kinase 3 [D08.811.913.696.620.682.700.646.500.812]
        
        Cyclin-Dependent Kinase 4 [D08.811.913.696.620.682.700.646.500.875]
        
        Cyclin-Dependent Kinase 6 [D08.811.913.696.620.682.700.646.500.937]
        
        Cyclin-Dependent Kinase 8 [D08.811.913.696.620.682.700.646.500.968]
        
        Maturation-Promoting Factor [D08.811.913.696.620.682.700.646.500.984]
        
        Cyclin-Dependent Kinase-Activating Kinase [D08.811.913.696.620.682.700.646.500.992]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Adaptor Proteins, Signal Transducing [D12.776.157.057]
      - Mediator Complex [D12.776.157.057.072]
        
        Cyclin C [D12.776.157.057.072.249]
        
        Cyclin-Dependent Kinase 8 [D12.776.157.057.072.500]
        
        Mediator Complex Subunit 1 [D12.776.157.057.072.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Cell Cycle Proteins [D12.776.167]
    - Cyclin-Dependent Kinases [D12.776.167.200]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Adaptor Proteins, Signal Transducing [D12.776.476.024]
      - Mediator Complex [D12.776.476.024.388]
        
        Cyclin C [D12.776.476.024.388.249]
        
        Cyclin-Dependent Kinase 8 [D12.776.476.024.388.500]
        
        Mediator Complex Subunit 1 [D12.776.476.024.388.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - Proline-Directed Protein Kinases [D12.776.476.563.646]
        
        Cyclin-Dependent Kinases [D12.776.476.563.646.500]
        
        CDC2-CDC28 Kinases [D12.776.476.563.646.500.500]
        
        Cyclin-Dependent Kinase 2 [D12.776.476.563.646.500.750]
        
        Cyclin-Dependent Kinase 3 [D12.776.476.563.646.500.812]
        
        Cyclin-Dependent Kinase 4 [D12.776.476.563.646.500.875]
        
        Cyclin-Dependent Kinase 6 [D12.776.476.563.646.500.937]
        
        Cyclin-Dependent Kinase 8 [D12.776.476.563.646.500.968]
        
        Maturation-Promoting Factor [D12.776.476.563.646.500.984]
        
        Cyclin-Dependent Kinase-Activating Kinase [D12.776.476.563.646.500.992]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nuclear Proteins [D12.776.660]
    - Mediator Complex [D12.776.660.551]

Cyclin-Dependent Kinase 8 Preferred

Concept UI: M0529506
Related Numbers: EC 2.7.11.23
Scope Note: A CYCLIN C dependent kinase that is an important component of the mediator complex. The enzyme is activated by its interaction with CYCLIN C and plays a role in transcriptional regulation by phosphorylating RNA POLYMERASE II.
Terms: Cyclin-Dependent Kinase 8 Preferred Term
Term UI T735092
Date02/13/2009
LexicalTag NON
ThesaurusID NLM (2010); Cell Division Protein Kinase 8
Term UI T735195
Date02/17/2009
LexicalTag NON
ThesaurusID NLM (2010); Cdk8 Cyclin-Dependent Kinase
Term UI T748400
Date03/30/2009
LexicalTag ABX
ThesaurusID NLM (2010); Cdk8 Protein Kinase
Term UI T748401
Date03/30/2009
LexicalTag ABX
ThesaurusID NLM (2010)

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