MeSH Browser

MeSH Heading: Mediator Complex Subunit 1
Tree Number(s): D05.500.374.750; D12.644.360.024.309.750; D12.644.360.024.314.049; D12.776.157.057.072.750; D12.776.157.057.080.049; D12.776.476.024.388.750; D12.776.476.024.394.049; D12.776.660.551.750; D12.776.660.675.049; D12.776.930.617.049
Unique ID: D056913
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D056913
Scope Note: A mediator complex subunit that is believed to play a key role in the coactivation of nuclear receptor-activated transcription by the mediator complex. It interacts with a variety of nuclear receptors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; VITAMIN D RECEPTORS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; ESTROGEN RECEPTORS; and GLUCOCORTICOID RECEPTORS.
Entry Term(s): DRIP205; Mediator of RNA Polymerase II Transcription Subunit 1; PPAR-Binding Protein; Peroxisome Proliferator-Activated Receptor Binding Protein; RB18A; TR-Associated Protein P220; TRAP220; TRIP2 (Thyroid Receptor Interacting Protein 2); Thyroid Hormone Receptor Associated Protein 220; Thyroid Receptor Interacting Protein 2; Vitamin D Receptor-Interacting Protein Complex Component DRIP205; p53 Regulatory Protein RB18A
Registry Numbers: 0
Public MeSH Note: 2010; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTIION SUBUNIT 1 (now MEDIATOR COMPLEX SUBUNIT 1) was indexed under TRANSCRIPTION FACTORS 1998-2009
History Note: 2010(1998)
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2016/03/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Macromolecular Substances [D05]
- Multiprotein Complexes [D05.500]
  - Mediator Complex [D05.500.374]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Adaptor Proteins, Signal Transducing [D12.644.360.024]
      - Mediator Complex [D12.644.360.024.309]
        
        Cyclin C [D12.644.360.024.309.249]
        
        Mediator Complex Subunit 1 [D12.644.360.024.309.750]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Adaptor Proteins, Signal Transducing [D12.644.360.024]
      - Nuclear Receptor Coactivators [D12.644.360.024.314]
        
        Mediator Complex Subunit 1 [D12.644.360.024.314.049]
        
        Nuclear Receptor Coactivator 1 [D12.644.360.024.314.100]
        
        Nuclear Receptor Coactivator 2 [D12.644.360.024.314.200]
        
        Nuclear Receptor Coactivator 3 [D12.644.360.024.314.300]
        
        Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha [D12.644.360.024.314.650]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Adaptor Proteins, Signal Transducing [D12.776.157.057]
      - Mediator Complex [D12.776.157.057.072]
        
        Cyclin C [D12.776.157.057.072.249]
        
        Cyclin-Dependent Kinase 8 [D12.776.157.057.072.500]
        
        Mediator Complex Subunit 1 [D12.776.157.057.072.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Adaptor Proteins, Signal Transducing [D12.776.157.057]
      - Nuclear Receptor Coactivators [D12.776.157.057.080]
        
        Mediator Complex Subunit 1 [D12.776.157.057.080.049]
        
        Nuclear Receptor Coactivator 1 [D12.776.157.057.080.100]
        
        Nuclear Receptor Coactivator 2 [D12.776.157.057.080.200]
        
        Nuclear Receptor Coactivator 3 [D12.776.157.057.080.300]
        
        Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha [D12.776.157.057.080.650]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Adaptor Proteins, Signal Transducing [D12.776.476.024]
      - Mediator Complex [D12.776.476.024.388]
        
        Cyclin C [D12.776.476.024.388.249]
        
        Cyclin-Dependent Kinase 8 [D12.776.476.024.388.500]
        
        Mediator Complex Subunit 1 [D12.776.476.024.388.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Adaptor Proteins, Signal Transducing [D12.776.476.024]
      - Nuclear Receptor Coactivators [D12.776.476.024.394]
        
        Mediator Complex Subunit 1 [D12.776.476.024.394.049]
        
        Nuclear Receptor Coactivator 1 [D12.776.476.024.394.100]
        
        Nuclear Receptor Coactivator 2 [D12.776.476.024.394.200]
        
        Nuclear Receptor Coactivator 3 [D12.776.476.024.394.300]
        
        Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha [D12.776.476.024.394.650]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nuclear Proteins [D12.776.660]
    - Mediator Complex [D12.776.660.551]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nuclear Proteins [D12.776.660]
    - Nuclear Receptor Coactivators [D12.776.660.675]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Transcription Factors [D12.776.930]
    - Nuclear Receptor Coactivators [D12.776.930.617]

Mediator Complex Subunit 1 Preferred

Mediator Complex Subunit 1 MeSH Descriptor Data 2025